… Using zebrafish as a deafness model, Pacentine and Nicolson demonstrate that Tmie is
required for the localization of the channel subunits, transmembrane channel-like (Tmc) proteins …

G protein−coupled receptors (GPCRs) regulate facets of growth, development, and environmental
sensing in eukaryotes, including filamentous fungi. The largest predicted GPCR class …

Protocadherin 15 (PCDH15) is required for mechanotransduction in sensory hair cells as a
component of the tip link. Isoforms of PCDH15 differ in their cytoplasmic domains (CD1, CD2, …

Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting
mechanical stimuli into electrical signals. This process of mechano-electrical transduction …

ATP-utilizing enzymes play key roles in hair bundles, the mechanically sensitive organelles
of sensory hair cells in the inner ear. We used a fluorescent ATP analog, EDA-ATP-Cy3 (Cy3-…

The senses of hearing and balance are subject to modulation by efferent signaling, including
the release of dopamine (DA). How DA influences the activity of the auditory and vestibular …

Sensory hair cells of the inner ear rely on the hair bundle, a cluster of actin-filled stereocilia,
to transduce auditory and vestibular stimuli into electrical impulses. Because they are long …

Detection of sound and head movement requires mechanoelectrical transduction (MET)
channels at tips of hair-cell stereocilia. In vertebrates, the transmembrane channel-like (TMC) …

ATP-utilizing enzymes play key roles in hair bundles, the mechanically sensitive organelles
of sensory hair cells in the inner ear. We used a fluorescent ATP analog, EDA-ATP-Cy3 (Cy3-…

… Using zebrafish as a deafness model, Pacentine and Nicolson demonstrate that Tmie is
required for the localization of other essential complex members, the transmembrane channel-…