User profiles for J Nathans

Jeremy Nathans

Professor of Molecular Biology and Genetics, Johns Hopkins University
Verified email at jhmi.edu
Cited by 42953

Tissue/planar cell polarity in vertebrates: new insights and new questions

Y Wang, J Nathans - 2007 - journals.biologists.com
This review focuses on the tissue/planar cell polarity (PCP) pathway and its role in generating
spatial patterns in vertebrates. Current evidence suggests that PCP integrates both global …

[PDF][PDF] The evolution and physiology of human color vision: insights from molecular genetic studies of visual pigments

J Nathans - Neuron, 1999 - cell.com
… structure of the red and green pigment genes (Nathans ceptor cells, and therefore the ratios
… green pigment gene array (Nathans et gene duplication event had placed the visual pigment …

Macular degeneration: recent advances and therapeutic opportunities

A Rattner, J Nathans - Nature Reviews Neuroscience, 2006 - nature.com
The central retina mediates high acuity vision, and its progressive dysfunction due to
macular degeneration is the leading cause of visual disability among adults in industrialized …

A new member of the frizzled family from Drosophila functions as a Wingless receptor

…, JC Hsieh, Y Wang, JP Macke, D Andrew, J Nathans… - Nature, 1996 - nature.com
… Scott and members of the Nathans and Nusse laboratories for discussions and comments
on the manuscript. MB was supported by a long-term fellowship from EMBO. These studies …

A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Starqardt macular dystrophy

…, Y Li, KL Anderson, RA Lewis, J Nathans… - Nature …, 1997 - nature.com
Stargardt disease (STGD, also known as fundus flavimaculatus; FFM) is an autosomal recessive
retinal disorder characterized by a juvenile-onset macular dystrophy, alterations of the …

Molecular genetics of human color vision: the genes encoding blue, green, and red pigments

J Nathans, D Thomas, DS Hogness - Science, 1986 - science.org
Human color vision is based on three light-sensitive pigments. The isolation and sequencing
of genomic and complementary DNA clones that encode the apoproteins of these three …

A new secreted protein that binds to Wnt proteins and inhibits their activites

…, CH Samos, R Nusse, IB Dawid, J Nathans - Nature, 1999 - nature.com
… b–j, WIF-1 mRNAs detected by in situ hybridization. b–f, Xenopus; g–j, zebrafish. Expression
is first detectable at the onset of somitogenesis in paraxial mesoderm (b, g). Expression is …

[HTML][HTML] Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

…, MW Kelley, L Jiang, W Tasman, K Zhang, J Nathans - Cell, 2004 - cell.com
… (J–L) Retinal flat mounts at P14 stained with GS-lectin and optically sectioned at the NFL (J),
outer edge of the IPL (K), and OPL (L). In the fz4 −/− retina, localized expansions develop …

Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.

…, CH Sung, J Nathans… - Proceedings of the …, 1994 - National Acad Sciences
Retinitis pigmentosa (RP) is a group of inherited human diseases in which photoreceptor
degeneration leads to visual loss and eventually to blindness. Although mutations in the …

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

…, NA Jenkins, J Nathans - Proceedings of the …, 1997 - National Acad Sciences
This paper describes the identification of a new family of mammalian genes that encode
secreted proteins containing homology to the cysteine-rich ligand-binding domain found in the …