User profiles for Jérémie Lefebvre

Jérémie Lefebvre

Associate Professor - University of Ottawa
Verified email at uottawa.ca
Cited by 1289

Activity-dependent myelination: A glial mechanism of oscillatory self-organization in large-scale brain networks

…, PW Frankland, D Mabbott, J Lefebvre - Proceedings of the …, 2020 - National Acad Sciences
Communication and oscillatory synchrony between distributed neural populations are
believed to play a key role in multiple cognitive and neural functions. These interactions are …

[HTML][HTML] Modulation of cortical oscillations by low-frequency direct cortical stimulation is state-dependent

S Alagapan, SL Schmidt, J Lefebvre, E Hadar… - PLoS …, 2016 - journals.plos.org
Cortical oscillations play a fundamental role in organizing large-scale functional brain
networks. Noninvasive brain stimulation with temporally patterned waveforms such as repetitive …

Shaping intrinsic neural oscillations with periodic stimulation

…, MM Murray, S Ionta, A Hutt, J Lefebvre - Journal of …, 2016 - Soc Neuroscience
Rhythmic brain activity plays an important role in neural processing and behavior. Features
of these oscillations, including amplitude, phase, and spectrum, can be influenced by …

[HTML][HTML] Neurostimulation stabilizes spiking neural networks by disrupting seizure-like oscillatory transitions

S Rich, A Hutt, FK Skinner, TA Valiante, J Lefebvre - Scientific reports, 2020 - nature.com
An improved understanding of the mechanisms underlying neuromodulatory approaches to
mitigate seizure onset is needed to identify clinical targets for the treatment of epilepsy. …

[PDF][PDF] Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony

S Rich, HM Chameh, J Lefebvre, TA Valiante - Cell Reports, 2022 - cell.com
A myriad of pathological changes associated with epilepsy can be recast as decreases in cell
and circuit heterogeneity. We thus propose recontextualizing epileptogenesis as a process …

[HTML][HTML] State-dependent alpha peak frequency shifts: Experimental evidence, potential mechanisms and functional implications

A Mierau, W Klimesch, J Lefebvre - neuroscience, 2017 - Elsevier
Neural populations produce complex oscillatory patterns thought to implement brain function.
The dominant rhythm in the healthy adult human brain is formed by alpha oscillations with …

Stochastic resonance mediates the state-dependent effect of periodic stimulation on cortical alpha oscillations

J Lefebvre, A Hutt, F Frohlich - Elife, 2017 - elifesciences.org
10.7554/eLife.32054.001 Brain stimulation can be used to engage and modulate rhythmic
activity in brain networks. However, the outcomes of brain stimulation are shaped by …

Stimulus statistics shape oscillations in nonlinear recurrent neural networks

J Lefebvre, A Hutt, JF Knebel… - Journal of …, 2015 - Soc Neuroscience
Rhythmic activity plays a central role in neural computations and brain functions ranging
from homeostasis to attention, as well as in neurological and neuropsychiatric disorders. …

[HTML][HTML] Dynamic control of synchronous activity in networks of spiking neurons

A Hutt, A Mierau, J Lefebvre - PloS one, 2016 - journals.plos.org
Oscillatory brain activity is believed to play a central role in neural coding. Accumulating
evidence shows that features of these oscillations are highly dynamic: power, frequency and …

Homeostatic coordination and up-regulation of neural activity by activity-dependent myelination

…, PW Frankland, D Mabbott, J Lefebvre - Nature Computational …, 2022 - nature.com
Activity-dependent myelination (ADM) is a fundamental dimension of brain plasticity through
which myelin changes as a function of neural activity. Mediated by structural changes in glia…