5-HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Over the past decade, there has been increasing interest in the role of serotonin 6 (5-HT 6 )
receptors in higher cognitive processes such as memory. Polymorphisms of the 5-HT 6 …

Neurotransmission by serotonin (5-HT) is tightly regulated by several autoreceptors that fine-tune
serotonergic neurotransmission through negative feedback inhibition at the cell bodies …

Dorsal striatum is important for the development of drug addiction; however, a precise
understanding of the roles of striatopallidal (indirect) and striatonigral (direct) pathway neurons in …

Although chronic cocaine-induced changes in dendritic spines on nucleus accumbens (NAc)
neurons have been correlated with behavioral sensitization, the molecular pathways …

Maladaptive responses to stress adversely affect human behavior, yet the signaling mechanisms
underlying stress-responsive behaviors remain poorly understood. Using a conditional …

Rodents engage in social communication through a rich repertoire of ultrasonic vocalizations
(USVs). Recording and analysis of USVs has broad utility during diverse behavioral tests …

BACKGROUND: Ovarian steroids modulate anxiety behavior, perhaps by regulating the
serotonergic neurons in the midbrain raphe nucleus. The regulation of the brain-specific isoform …

The ovarian steroids, estrogen (E) and progesterone (P), have been shown to affect anxiety
and fear in humans and animals, although with inconsistent results. These ambiguous …

Rationale Although serotonin (5-HT) dysregulation is implicated in the pathophysiology of
major depressive disorder (MDD), the role of specific receptor subtypes remains to be …