Intracellular Ca 2+ initiates physiological events as diverse as gene transcription, muscle
contraction, cell division and exocytosis. Predictably, the metabolic machinery that elicits and …

… Rodriguez, and DB Ehlenberger, and other members of the Hof, Morrison, Wearne, and
Luebke laboratories who have been involved in our studies of brain aging for their support. This …

N-type calcium channels play a dominant role in controlling synaptic transmission in many
peripheral neurons. Transmitter release from mammalian central nerve terminals, however, is …

An electron microscopic analysis has been carried out on the effects of age on the numerical
density of both excitatory (asymmetric) and inhibitory (symmetric) synapses in the neuropil …

… The authors thank all the members of the Dickstein, Luebke, Weaver, and Hof laboratories
for their participation in these studies. This work was supported by NIH Grants MH071818, …

Neurofibrillary tangles (NFT), intracellular inclusions of abnormal fibrillar forms of microtubule
associated protein tau, accumulate in Alzheimer's disease (AD) and other tauopathies and …

Extracellular vesicles are highly transmissible and play critical roles in the propagation of tau
pathology, although the underlying mechanism remains elusive. Here, for the first time, we …

In the rTg4510 mouse model, expression of the mutant human tau variant P301L leads to
development of neurofibrillary tangles (NFTs), neuronal death, and memory impairment, …

We have previously shown that myelin abnormalities characterize the normal aging process
of the brain and that an age-associated reduction in Klotho is conserved across species. …

Executive system function, mediated largely by the prefrontal cortex (PFC), often declines
significantly with normal aging in humans and non-human primates. The neural substrates of …