Epidemiological studies associate post-menopausal estrogen use with a reduction in risk of
Alzheimer’s disease, a reduction in risk of Parkinson’s disease, and death from stroke. The …

There is ample empirical evidence to support the notion that the biological impacts of
estrogen extend beyond the gonads to other bodily systems, including the brain and behavior. …

Inflammatory mechanisms both in the periphery and in the CNS are important in the
pathophysiologic processes occurring after the onset of ischemic stroke (IS). Cytokines are key …

✓ The present study was undertaken to determine if estrogens protect female rats from the
neurodegenerative effects of middle cerebral artery (MCA) occlusion. The rats were …

… and Simpkins, JW, The effect of estradiol deprivation and replacement on high affinity
choline uptake in frontal cortex and hippocampus of female Sprague-Dawley rats, Endocr. Soc. …

Estrogen receptors (ERs) are believed to be ligand-activated transcription factors belonging
to the nuclear receptor superfamily, which on ligand binding translocate into the nucleus …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose etiology is
presently unknown. Probably the most consistent and widespread deficit seen in this syndrome …

β-site APP-cleaving enzyme (BACE) is required for production of the Alzheimer's disease (AD)-associated
Aβ protein. BACE levels are elevated in AD brain, and increasing evidence …

Four agents — acarbose ( ACA ), 17‐α‐estradiol ( EST ), nordihydroguaiaretic acid ( NDGA ),
and methylene blue ( MB ) — were evaluated for lifespan effects in genetically …

The National Institute on Aging Interventions Testing Program ( ITP ) evaluates agents
hypothesized to increase healthy lifespan in genetically heterogeneous mice. Each compound is …