Nine different antibody–drug conjugates (ADCs) are currently approved as cancer treatments,
with dozens more in preclinical and clinical development. The primary goal of ADCs is to …

The development of anti-HER2 agents has been one of the most meaningful advancements
in the management of metastatic breast cancer, significantly improving survival outcomes. …

A high index of suspicion for penile cancer and a low threshold for biopsy of all penile lesions
that do not respond to a short trial of conservative therapy are the primary requirements for …

To gain insight into the function of peroxisome proliferator-activated receptor (PPAR)
isoforms in rodents, we disrupted the ligand-binding domain of the α isoform of mouse PPAR (…

GLIAL-CELL-LINE-DERIVED neurotrophic factor (GDNF) has been isolated as a neurotrophic
factor for midbrain dopaminergic neurons 1 . Because of its neurotrophic activity on a wide …

The common y chain (yc) of the IL-2, 11-4, IL-7, IL-g, and IL-15 receptors is defective in
humans with XSCID. Mice lacking ys expression had hypoplastic thymuses; the thymocytes …

Insulin action is viewed as a set of branching pathways, with some actions serving to regulate
energy metabolism and others to regulate cellular growth and development 1 . Thus far, …

While most effects of dopamine in the brain are mediated by the D1 and D2 receptor
subtypes, other members of this G protein-coupled receptor family have potentially important …

We investigated the function of Lhx2, a LIM homeobox gene expressed in developing B-cells,
forebrain and neural retina, by analyzing embryos deficient in functional Lhx2 protein. …

Pharmacological evaluation of nicotine-stimulated dopamine release from striatum has yielded
data consistent with activation of a single population of nicotinic acetylcholine receptors (…