Although the basic principles underlying the function of the peripheral auditory system have
been known for many years, the molecules required for hearing have hitherto remained …

Autosomal recessive genetic forms (DFNB) account for most cases of profound congenital
deafness. Adeno-associated virus (AAV)-based gene therapy is a promising therapeutic option…

Deconvolution algorithms have proven very effective in conventional (wide-field)
fluorescence microscopy. Their application to confocal microscopy is hampered, in biological …

10.7554/eLife.31013.001 Hearing relies on rapid, temporally precise, and sustained
neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This …

Our understanding of the mechanisms underlying inherited forms of inner ear deficits has
considerably improved during the past 20 y, but we are still far from curative treatments. We …

During sound stimulation, receptor potentials are generated within the sensory hair cells of
the cochlea. Prevailing theory states that outer hair cells use the potential-sensitive motor …

The cochlea contains two types of sensory cells, the inner and outer hair cells. Sound-evoked
deflection of outer hair cell stereocilia leads to fast force production that will enhance …

Deconvolution algorithms are widely used in conventional fluorescence microscopy, but
they remain difficult to apply to deep imaging systems such as confocal and two-photon …

Usher syndrome type 1 (USH1) causes combined hearing and sight defects, but how mutations
in USH1 genes lead to retinal dystrophy in patients remains elusive. The USH1 protein …

The precise architecture of hair bundles, the arrays of mechanosensitive microvilli-like stereocilia
crowning the auditory hair cells, is essential to hearing. Myosin IIIa, defective in the late-…