User profiles for Jae K. Lee
Jae K LeeUniversity of Miami Verified email at med.miami.edu Cited by 5351 |
A gene expression database for the molecular pharmacology of cancer
We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell
lines used in a drug discovery screen by the National Cancer Institute. Using these data, we …
lines used in a drug discovery screen by the National Cancer Institute. Using these data, we …
PTEN deletion enhances the regenerative ability of adult corticospinal neurons
Despite the essential role of the corticospinal tract (CST) in controlling voluntary movements,
successful regeneration of large numbers of injured CST axons beyond a spinal cord lesion …
successful regeneration of large numbers of injured CST axons beyond a spinal cord lesion …
Chemosensitivity prediction by transcriptional profiling
…, MJ Angelo, J Park, U Scherf, JK Lee… - Proceedings of the …, 2001 - National Acad Sciences
In an effort to develop a genomics-based approach to the prediction of drug response, we
have developed an algorithm for classification of cell line chemosensitivity based on gene …
have developed an algorithm for classification of cell line chemosensitivity based on gene …
Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays
…, H Kouros-Mehr, KJ Bussey, JK Lee… - Proceedings of the …, 2003 - National Acad Sciences
Because most potential molecular markers and targets are proteins, proteomic profiling is
expected to yield more direct answers to functional and pharmacological questions than does …
expected to yield more direct answers to functional and pharmacological questions than does …
Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury
…, C Lai-Hsu, KK Park, P Tsoulfas, JK Lee - Journal of …, 2013 - Soc Neuroscience
Injury to the CNS leads to formation of scar tissue, which is important in sealing the lesion
and inhibiting axon regeneration. The fibrotic scar that comprises a dense extracellular matrix …
and inhibiting axon regeneration. The fibrotic scar that comprises a dense extracellular matrix …
[PDF][PDF] Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice
JK Lee, CG Geoffroy, AF Chan, KE Tolentino… - Neuron, 2010 - cell.com
A central hypothesis for the limited capacity for adult central nervous system (CNS) axons to
regenerate is the presence of myelin-derived axon growth inhibitors, the role of which, …
regenerate is the presence of myelin-derived axon growth inhibitors, the role of which, …
Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study
…, DA Scudiero, E Petricoin, L Liotta, JK Lee… - Molecular cancer …, 2007 - AACR
To evaluate the utility of transcript profiling for prediction of protein expression levels, we
compared profiles across the NCI-60 cancer cell panel, which represents nine tissues of origin. …
compared profiles across the NCI-60 cancer cell panel, which represents nine tissues of origin. …
Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays
Motivation: In microarray studies gene discovery based on fold-change values is often
misleading because error variability for each gene is heterogeneous under different biological …
misleading because error variability for each gene is heterogeneous under different biological …
A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery
JK Lee, DM Havaleshko, HJ Cho… - Proceedings of the …, 2007 - National Acad Sciences
The US National Cancer Institute has used a panel of 60 diverse human cancer cell lines (the
NCI-60) to screen >100,000 chemical compounds for anticancer activity. However, not all …
NCI-60) to screen >100,000 chemical compounds for anticancer activity. However, not all …
Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract
…, YP Zhang, CB Shields, JK Lee… - Proceedings of the …, 2012 - National Acad Sciences
Axon regeneration in the central nervous system normally fails, in part because of a developmental
decline in the intrinsic ability of CNS projection neurons to extend axons. Members of …
decline in the intrinsic ability of CNS projection neurons to extend axons. Members of …