Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior

JJA Contos, N Fukushima, JA Weiner… - Proceedings of the …, 2000 - National Acad Sciences
Although extracellular application of lysophosphatidic acid (LPA) has been extensively
documented to produce a variety of cellular responses through a family of specific G protein-…

LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing

X Ye, K Hama, JJA Contos, B Anliker, A Inoue… - Nature, 2005 - nature.com
Every successful pregnancy requires proper embryo implantation. Low implantation rate is a
major problem during infertility treatments using assisted reproductive technologies 1 . Here …

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

M Inoue, MH Rashid, R Fujita, JJA Contos, J Chun… - Nature medicine, 2004 - nature.com
Lysophosphatidic acid (LPA) is a bioactive lipid with activity in the nervous system mediated
by G-protein-coupled receptors. Here, we examined the role of LPA signaling in the …

Lysophosphatidic acid receptors

JJA Contos, I Ishii, J Chun - Molecular pharmacology, 2000 - ASPET
Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological
actions on many cell types. LPA induces proliferative and/or morphological effects and has …

Lysophospholipid receptors

…, I Ishii, JJA Contos, JA Weiner… - Annual review of …, 2001 - annualreviews.org
Lysophospholipids (LPs), including lysophosphatidic acid and sphingosine 1-phosphate,
produce many cellular effects. However, the prolonged absence of any cloned and identified …

Characterization of lpa2 (Edg4) and lpa1/lpa2 (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality …

JJA Contos, I Ishii, N Fukushima… - … and cellular biology, 2002 - Taylor & Francis
Lysophosphatidic acid (LPA), a bioactive lipid produced by several cell types including
postmitotic neurons and activated platelets, is thought to be involved in various biological …

[HTML][HTML] Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3

…, X Ye, S Kawamura, C McGiffert, JJA Contos… - Journal of Biological …, 2001 - ASBMB
Sphingosine 1-phosphate (S1P) exerts diverse physiological actions by activating its cognate
G protein-coupled receptors. Five S1P receptors have been identified in mammals: LP B1 /…

Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding

MA Kingsbury, SK Rehen, JJA Contos… - Nature …, 2003 - nature.com
Lysophosphatidic acid (LPA) is a phospholipid that has extracellular signaling properties
mediated by G protein–coupled receptors. Two LPA receptors, LPA 1 and LPA 2 , are …

[HTML][HTML] Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3 …

…, X Ye, B Friedman, S Kawamura, JJA Contos… - Journal of Biological …, 2002 - ASBMB
Five cognate G protein-coupled receptors (S1P 1–5 ) have been shown to mediate various
cellular effects of sphingosine 1-phosphate (S1P). Here we report the generation of mice null …

Functional comparisons of the lysophosphatidic acid receptors, LPA1/VZG-1/EDG-2, LPA2/EDG-4, and LPA3/EDG-7 in neuronal cell lines using a retrovirus …

I Ishii, JJA Contos, N Fukushima, J Chun - Molecular Pharmacology, 2000 - ASPET
Lysophosphatidic acid (LPA) is a potent lipid mediator with diverse physiological actions on
a wide variety of cells and tissues. Three cognate G-protein-coupled receptors have been …