During limb development, digits emerge from the undifferentiated mesenchymal tissue that
constitutes the limb bud. It has been proposed that this process is controlled by a self-…

Still the only general survey of the topic available, this widely-used exploration of the incidence,
causes and control of crime in Early Modern England throws a vivid light on the times. It …

Although the vertebrate limb bud has been studied for decades as a model system for spatial
pattern formation and cell specification, the cellular basis of its distally oriented elongation …

Current techniques for three-dimensional (3D) optical microscopy (deconvolution, confocal
microscopy, and optical coherence tomography) generate 3D data by “optically sectioning” …

I am grateful to Dr MJ Ingram, Dr WJ Sheils, and Mr Keith Thomas for reading earlier drafts
of this pamphlet. The final version owes much to their comments, although such errors of fact …

Senescence is a form of cell-cycle arrest linked to tumor suppression and aging. However, it
remains controversial and has not been documented in nonpathologic states. Here we …

On 17 April 1680 the tranquillity of the Essex parish of West Ham was disrupted by the public
execution for murder of one of its inhabitants, John Marketman. The circumstances of the …

We quantified the horizontal pursuit and saccadic function of 14 parkinsonian patients and 10
normal subjects matched for age. Eight patients had mild, and 6 advanced disease. Ocular …

The formation of repetitive structures (such as stripes) in nature is often consistent with a
reaction-diffusion mechanism, or Turing model, of self-organizing systems. We used mouse …

One of the most fundamental questions in biology is that of biological pattern: how do the
structures and shapes of organisms arise? Undoubtedly, the two most influential ideas in this …