Homeostatic plasticity may compensate for Hebbian forms of synaptic plasticity, such as long-term
potentiation (LTP) and depression (LTD), by scaling neuronal output without changing …

The neuropathological correlates of Alzheimer's disease (AD) include amyloid-β (Aβ) plaques
and neurofibrillary tangles. To study the interaction between Aβ and tau and their effect on …

The cellular processes that govern neuronal function are highly complex, with many basic
cell biological pathways uniquely adapted to perform the elaborate information processing …

Arc/Arg3.1 is an immediate-early gene whose mRNA is rapidly transcribed and targeted to
dendrites of neurons as they engage in information processing and storage. Moreover, Arc/…

Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that
requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced …

The neuronal gene Arc is essential for long-lasting information storage in the mammalian
brain, mediates various forms of synaptic plasticity, and has been implicated in …

Many proteins have been implicated in synaptic and experience-dependent plasticity.
However, few demonstrate the exquisite regulation of expression and breadth of functional …

Assemblies of β-amyloid (Aβ) peptides are pathological mediators of Alzheimer's Disease (AD)
and are produced by the sequential cleavages of amyloid precursor protein (APP) by β-…

Neuronal activation induces rapid transcription of immediate early genes (IEGs) and longer-term
chromatin remodeling around secondary response genes (SRGs). Here, we use high-…

A myriad of mechanisms have been suggested to account for the full richness of visual cortical
plasticity. We found that visual cortex lacking Arc is impervious to the effects of deprivation …