In the mammalian inner ear, the gain control of auditory inputs is exerted by medial olivocochlear
(MOC) neurons that innervate cochlear outer hair cells (OHCs). OHCs mechanically …

Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models,
recovery of behavioral and neurophysiological deficits using GABA A R antagonists led to …

Background and Purpose Excessive GABAergic inhibition contributes to cognitive
dysfunctions in Down syndrome (DS). Selective negative allosteric modulators (NAMs) of α5‐…

Down syndrome (DS), also known as trisomy 21, is the most common genetic cause of
intellectual disability. It is also a model human disease for exploring consequences of gene …

Key points GABA A receptors have been described in the axonal compartment of neurons;
contrary to dendritic GABA A receptors, axonal GABA A receptors usually induce depolarizing …

… , Joana Lourenço, Marie-Claude Potier, Javier Zorrilla de San Martin and Alberto Bacci …
.bacci{at}icm-institute.org or Javier Zorrilla de San Martin at javier.zorrilla{at}icm-institute.org …

The synapse between olivocochlear (OC) neurons and cochlear mechanosensory hair cells
is cholinergic, fast, and inhibitory. The inhibitory sign of this cholinergic synapse is …

In several types of central mammalian synapses, sustained presynaptic stimulation leads to
a sequence of two components of synaptic vesicle release, reflecting the consecutive …

In the mammalian auditory system, the synapse between efferent olivocochlear (OC) neurons
and sensory cochlear hair cells is cholinergic, fast, and inhibitory. This efferent synapse is …

In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent
fibers that convey sound information to the CNS. During postnatal development, however, …