User profiles for Jean X. Jiang

Jiang Jean X.

University of Texas Health Science Center at San Antonio
Verified email at uthscsa.edu
Cited by 24763

Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases

DA Callaway, JX Jiang - Journal of bone and mineral metabolism, 2015 - Springer
Osteoclasts are cells derived from bone marrow macrophages and are important in
regulating bone resorption during bone homeostasis. Understanding what drives osteoclast …

Biological role of connexin intercellular channels and hemichannels

R Kar, N Batra, MA Riquelme, JX Jiang - Archives of biochemistry and …, 2012 - Elsevier
Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called connexins
are transmembrane conduits for the exchange of small molecules and ions. Connexins …

[HTML][HTML] Gap junction and hemichannel-independent actions of connexins on cell and tissue functions–an update

JZ Zhou, JX Jiang - FEBS letters, 2014 - Elsevier
Connexins, a family of transmembrane proteins, are components of both gap junction channels
and hemichannels, which mediate the exchange of ions and small molecules between …

Negative feedback control of neuronal activity by microglia

…, A Kahan, M Ishikawa, YC Wang, YHE Loh, JX Jiang… - Nature, 2020 - nature.com
Microglia, the brain’s resident macrophages, help to regulate brain function by removing dying
neurons, pruning non-functional synapses, and producing ligands that support neuronal …

Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin

…, LF Bonewald, E Sprague, JX Jiang - Molecular biology of …, 2005 - Am Soc Cell Biol
Mechanosensing bone osteocytes express large amounts of connexin (Cx)43, the component
of gap junctions; yet, gap junctions are only active at the small tips of their dendritic …

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

JA Orellana, N Froger, P Ezan, JX Jiang… - Journal of …, 2011 - Wiley Online Library
… After three rinses in 0.1% PBS-Triton X-100, cells were then incubated for 50 min at room
temperature with both goat anti-mouse Alexa Fluor 355 (1 : 1500) and isolectin GS-IB4 (1 : 100)…

Amyloid β-induced death in neurons involves glial and neuronal hemichannels

…, P Ezan, E Amigou, PJ Sáez, JX Jiang… - Journal of …, 2011 - Soc Neuroscience
The mechanisms involved in Alzheimer's disease are not completely understood and how
glial cells contribute to this neurodegenerative disease remains to be elucidated. Because …

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels

…, E Sprague, MA Schwartz, JX Jiang - Proceedings of the …, 2012 - National Acad Sciences
The connexin 43 (Cx43) hemichannel (HC) in the mechanosensory osteocytes is a major
portal for the release of factors responsible for the anabolic effects of mechanical loading on …

Heteromeric connexons in lens gap junction channels.

JX Jiang, DA Goodenough - Proceedings of the National …, 1996 - National Acad Sciences
Gap junction channels are formed by paired oligomeric membrane hemichannels called
connexons, which are composed of proteins of the connexin family. Experiments with …

Expression of functional gap junctions and regulation by fluid flow in osteocyte‐like MLO‐Y4 cells

…, E Sprague, LF Bonewald, JX Jiang - Journal of Bone and …, 2001 - academic.oup.com
Osteocytes are thought to be mechanosensory cells that respond to mechanical stress by
sending signals to other bone cells to initiate bone remodeling. An osteocyte‐like cell line MLO…