Focal adhesion kinase (FAK) is activated following integrin engagement or stimulation of
transmembrane receptors. Autophosphorylation of FAK on Tyr-397 is a critical event, allowing …

In the striatum, dopamine D 1 and adenosine A 2A receptors stimulate the production of cAMP,
which is involved in neuromodulation and long-lasting changes in gene expression and …

A major aim of neurobiology today is to improve understanding of the signaling pathways
that couple rapid events, such as the action potential and neurotransmitter release, to long-…

Background Primitive brain tumors are the leading cause of cancer-related death in children.
Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and …

Cancer stem cells are increasingly recognized as major therapeutic targets. We report here
the isolation of glioma stem cells (GSCs) maintaining telomere length through a telomerase-…

In mammalian brain, dopaminergic (DA) cell bodies located in the ventral mesencephalon
give rise to meso-cortical, meso-limbic and meso-striatal systems. Among these, the meso-…

In order to identify markers of the two neuronal populations which are successively involved
in forebrain ontogenesis, we performed a differential screening of a murine cDNA library …

pp125 focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase transducing signals initiated
by integrin engagement and G protein-coupled receptors, is highly expressed in brain. …

In brain, focal adhesion kinase (FAK) is regulated by neurotransmitters and has a higher
molecular mass than in other tissues, due to alternative splicing. Two exons code for additional …

Bilateral injections of 6-OHDA in the ventral mesencephalic tegmentum (VMT) destroy the
DA afferents of the nucleus accumbens but do not induce any denervation supersensitivity of …