[PDF][PDF] Axoplasmic importins enable retrograde injury signaling in lesioned nerve
…, M Koltzenburg, M Kohler, J van-Minnen, JL Twiss… - Neuron, 2003 - cell.com
Axoplasmic proteins containing nuclear localization signals (NLS) signal retrogradely by an
unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin α …
unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin α …
Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons
…, J Sylvester, J van Minnen, JL Twiss - Journal of …, 2005 - Soc Neuroscience
Recent studies have begun to focus on the signals that regulate axonal protein synthesis and
the functional significance of localized protein synthesis. However, identification of proteins …
the functional significance of localized protein synthesis. However, identification of proteins …
Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization
…, KH Zivraj, D Willis, G Coppola, BYH Lam, JL Twiss… - Rna, 2011 - rnajournal.cshlp.org
mRNAs are transported, localized, and translated in axons of sensory neurons. However,
little is known about the full repertoire of transcripts present in embryonic and adult sensory …
little is known about the full repertoire of transcripts present in embryonic and adult sensory …
HDAC6 is a target for protection and regeneration following injury in the nervous system
…, AP Kozikowski, SR Jaffrey, JL Twiss… - Proceedings of the …, 2009 - National Acad Sciences
Central nervous system (CNS) trauma can result in tissue disruption, neuronal and axonal
degeneration, and neurological dysfunction. The limited spontaneous CNS repair in …
degeneration, and neurological dysfunction. The limited spontaneous CNS repair in …
A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons
…, AK Rajasekaran, KC Martin, JL Twiss - Journal of …, 2001 - Soc Neuroscience
Although intradendritic protein synthesis has been documented in adult neurons, the
question of whether axons actively synthesize proteins remains controversial. Adult sensory …
question of whether axons actively synthesize proteins remains controversial. Adult sensory …
An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
…, D Katsman, SV Kozlov, CJ Donnelly, JL Twiss… - Nature …, 2010 - nature.com
Stroke is an age-related disease. Recovery after stroke is associated with axonal sprouting
in cortex adjacent to the infarct. The molecular program that induces a mature cortical neuron …
in cortex adjacent to the infarct. The molecular program that induces a mature cortical neuron …
Axonal transcription factors signal retrogradely in lesioned peripheral nerve
Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral
neurons. The involvement of importins in retrograde transport suggests that transcription …
neurons. The involvement of importins in retrograde transport suggests that transcription …
Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs
…, M Kendall, DS Smith, GJ Bassell, JL Twiss - The Journal of cell …, 2007 - rupress.org
Subcellular regulation of protein synthesis requires the correct localization of messenger
RNAs (mRNAs) within the cell. In this study, we investigate whether the axonal localization of …
RNAs (mRNAs) within the cell. In this study, we investigate whether the axonal localization of …
Voluntary exercise increases axonal regeneration from sensory neurons
…, Z Ying, F Gómez-Pinilla, JL Twiss - Proceedings of the …, 2004 - National Acad Sciences
Recent advances in understanding the role of neurotrophins on activity-dependent plasticity
have provided insight into how behavior can affect specific aspects of neuronal biology. We …
have provided insight into how behavior can affect specific aspects of neuronal biology. We …
[PDF][PDF] Mitochondria coordinate sites of axon branching through localized intra-axonal protein synthesis
M Spillane, A Ketschek, TT Merianda, JL Twiss, G Gallo - Cell reports, 2013 - cell.com
The branching of axons is a fundamental aspect of nervous system development and
neuroplasticity. We report that branching of sensory axons in the presence of nerve growth factor (…
neuroplasticity. We report that branching of sensory axons in the presence of nerve growth factor (…