The NLRP3 inflammasome: molecular activation and regulation to therapeutics
KV Swanson, M Deng, JPY Ting - Nature Reviews Immunology, 2019 - nature.com
NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that
detects a broad range of microbial motifs, endogenous danger signals and environmental …
detects a broad range of microbial motifs, endogenous danger signals and environmental …
[PDF][PDF] The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
…, DJ Taxman, EH Guthrie, RJ Pickles, JPY Ting - Immunity, 2009 - cell.com
The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition
molecules mediate host immunity to various pathogenic stimuli. However, in vivo …
molecules mediate host immunity to various pathogenic stimuli. However, in vivo …
[PDF][PDF] NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling
…, JM Uronis, HH Herfarth, C Jobin, AB Rogers, JPY Ting - Immunity, 2012 - cell.com
In vitro data suggest that a subgroup of NLR proteins, including NLRP12, inhibits the transcription
factor NF-κB, although physiologic and disease-relevant evidence is largely missing. …
factor NF-κB, although physiologic and disease-relevant evidence is largely missing. …
TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
…, M Marino, K Suzuki, GK Matsushima, JPY Ting - Nature …, 2001 - nature.com
Here we used mice lacking tumor necrosis factor-α (TNFα) and its associated receptors to
study a model of demyelination and remyelination in which these events could be carefully …
study a model of demyelination and remyelination in which these events could be carefully …
A new member of the leucine zipper class of proteins that binds to the HLA DRα promoter
…, R Davidon, N Nabavi, NJ Zeleznik-Le, JPY Ting… - Science, 1990 - science.org
Several mutants derived from transformed human B cell lines are defective in expressing
major histocompatibility complex (MHC) class II genes. The failure to express a class II gene in …
major histocompatibility complex (MHC) class II genes. The failure to express a class II gene in …
[PDF][PDF] NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING
Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular
DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (…
DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (…
Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication
…, ML Robb, RP Sekaly, X Chen, L Su, JPY Ting - Nature …, 2021 - nature.com
Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic
alterations of CD4 + T cells through unclear mechanisms with undefined consequences. We …
alterations of CD4 + T cells through unclear mechanisms with undefined consequences. We …
[PDF][PDF] An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2
Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19. Investigating
the underlying mechanisms, we find that while primary human airway epithelia (HAE) …
the underlying mechanisms, we find that while primary human airway epithelia (HAE) …
The inflammasome NLRs in immunity, inflammation, and associated diseases
BK Davis, H Wen, JPY Ting - Annual review of immunology, 2011 - annualreviews.org
Inflammasome activation leads to caspase-1 activation, which causes the maturation and
secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR (…
secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR (…
[PDF][PDF] The NLR gene family: a standard nomenclature
Immune regulatory proteins such as CIITA, NAIP, IPAF, NOD1, NOD2, NALP1, and cryopyrin
(also known as NALP3) are members of a family characterized by the presence of a NACHT …
(also known as NALP3) are members of a family characterized by the presence of a NACHT …