Mild cognitive impairment is characterized by deficient brainstem and cortical representations of speech

GM Bidelman, JE Lowther, SH Tak… - Journal of …, 2017 - Soc Neuroscience
Mild cognitive impairment (MCI) is recognized as a transitional phase in the progression
toward more severe forms of dementia and is an early precursor to Alzheimer's disease. …

[BOOK][B] Understanding the Subjective Norms Surrounding Noise Exposure and Hearing Conservation in Children

JE Lowther - 2012 - search.proquest.com
Hearing conservation programs (HCPs) often take an atheoretical, information-based approach
to reducing noise-induced hearing loss. This research assesses HCPs through a Theory …

[HTML][HTML] Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins

…, LB Poole, CM Furdui, WT Lowther - Journal of Biological …, 2018 - ASBMB
2-Cys peroxiredoxins (Prxs) modulate hydrogen peroxide (H 2 O 2 )-mediated cell signaling.
At high H 2 O 2 levels, eukaryotic Prxs can be inactivated by hyperoxidation and are …

[HTML][HTML] Crystal structure and substrate specificity of human thioesterase 2: insights into the molecular basis for the modulation of fatty acid synthase

…, BE Fulp, CM Furdui, SJ Kridel, WT Lowther - Journal of Biological …, 2016 - ASBMB
The type I fatty acid synthase (FASN) is responsible for the de novo synthesis of palmitate.
Chain length selection and release is performed by the C-terminal thioesterase domain (TE1). …

[HTML][HTML] Specificity of human sulfiredoxin for reductant and peroxiredoxin oligomeric state

…, JE Clodfelter, LC Johnson, CM Furdui, WT Lowther - Antioxidants, 2021 - mdpi.com
Human peroxiredoxins (Prx) are a family of antioxidant enzymes involved in a myriad of
cellular functions and diseases. During the reaction with peroxides (eg, H 2 O 2 ), the typical 2-…

Aromatic residues at the dimer− dimer interface in the peroxiredoxin Tsa1 facilitate decamer formation and biological function

…, JE Clodfelter, KA Morano, WT Lowther… - Chemical research in …, 2019 - ACS Publications
To prevent the accumulation of reactive oxygen species and limit associated damage to
biological macromolecules, cells express a variety of oxidant-detoxifying enzymes, including …

[HTML][HTML] Cannabinoid receptor interacting protein 1a interacts with myristoylated Gαi N terminus via a unique gapped β-barrel structure

…, EK Hughes, K Eldeeb, AC Howlett, WT Lowther - Journal of Biological …, 2021 - ASBMB
Cannabinoid receptor interacting protein 1a (CRIP1a) modulates CB 1 cannabinoid receptor
G-protein coupling in part by altering the selectivity for Gα i subtype activation, but the …

An outbreak of norovirus infection linked to oyster consumption at a UK restaurant, February 2010

…, N McCarthy, L Saldana, J Lowther… - Journal of public …, 2011 - academic.oup.com
Background We present the investigation of an outbreak of gastroenteritis at a UK restaurant
incorporating both epidemiological and microbiological analysis. Methods Structured postal …

Squeezed at the top: Interspecific aggression may constrain elevational ranges in tropical birds

JE Jankowski, SK Robinson, DJ Levey - Ecology, 2010 - Wiley Online Library
Tropical montane species are characterized by narrow elevational distributions. Recent
perspectives on mechanisms maintaining these restricted distributions have emphasized abiotic …

[HTML][HTML] Disabling mitochondrial peroxide metabolism via combinatorial targeting of peroxiredoxin 3 as an effective therapeutic approach for malignant mesothelioma

…, ET Chouchani, AM James, AC Haynes, WT Lowther… - PLoS …, 2015 - journals.plos.org
… Johnson and Jill E. Clodfelter for technical assistance. We also thank the UVM Proteomics
facility supported by the National Institute of General Medical Sciences of the National …