User profiles for John F. Cryan

John Cryan

University College Cork, Ireland
Verified email at ucc.ie
Cited by 110019

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

JF Cryan, TG Dinan - Nature reviews neuroscience, 2012 - nature.com
Recent years have witnessed the rise of the gut microbiota as a major topic of research
interest in biology. Studies are revealing how variations and changes in the composition of the …

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

…, TG Dinan, J Bienenstock, JF Cryan - Proceedings of the …, 2011 - National Acad Sciences
There is increasing, but largely indirect, evidence pointing to an effect of commensal gut
microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid …

Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

JF Cryan, RJ Valentino, I Lucki - Neuroscience & Biobehavioral Reviews, 2005 - Elsevier
Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
antidepressant class today and exert their antidepressant-like effects by increasing synaptic …

[HTML][HTML] The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS... 1907
IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 VI. …

Psychobiotics: a novel class of psychotropic

TG Dinan, C Stanton, JF Cryan - Biological psychiatry, 2013 - Elsevier
Here, we define a psychobiotic as a live organism that, when ingested in adequate amounts,
produces a health benefit in patients suffering from psychiatric illness. As a class of probiotic…

The microbiome‐gut‐brain axis: from bowel to behavior

JF Cryan, SM O'Mahony - Neurogastroenterology & Motility, 2011 - Wiley Online Library
The ability of gut microbiota to communicate with the brain and thus modulate behavior is
emerging as an exciting concept in health and disease. The enteric microbiota interacts with …

The gut microbiome in neurological disorders

JF Cryan, KJ O'Riordan, K Sandhu, V Peterson… - The Lancet …, 2020 - thelancet.com
Research into the role of the gut microbiome in modulating brain function has rapidly increased
over the past 10 years, albeit chiefly in animal models. Increasing clinical and preclinical …

Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat

…, G Moloney, AE Hoban, L Scott, P Fitzgerald… - Journal of psychiatric …, 2016 - Elsevier
The gut microbiota interacts with the host via neuroimmune, neuroendocrine and neural
pathways. These pathways are components of the brain-gut-microbiota axis and preclinical …

The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice

JF Cryan, C Mombereau, A Vassout - Neuroscience & Biobehavioral …, 2005 - Elsevier
Since its introduction almost 20 years ago, the tail suspension test has become one of the
most widely used models for assessing antidepressant-like activity in mice. The test is based …

Microbiota from young mice counteracts selective age-associated behavioral deficits

…, S Spichak, L Olavarría-Ramírez, P Fitzgerald… - Nature Aging, 2021 - nature.com
The gut microbiota is increasingly recognized as an important regulator of host immunity
and brain health. The aging process yields dramatic alterations in the microbiota, which is …