Neurodegenerative disorders are characterized by extensive neuron death that leads to
functional decline, but the neurobiological correlates of functional decline in normal aging are …

Specific patterns of neuronal firing induce changes in synaptic strength that may contribute
to learning and memory. If the postsynaptic NMDA (N-methyl-D-aspartate) receptors are …

Stressful life events have been implicated clinically in the pathogenesis of mental illness,
but the neural substrates that may account for this observation remain poorly understood. …

The prefrontal cortex (PFC) is involved in working memory and self-regulatory and goal-directed
behaviors and displays remarkable structural and functional plasticity over the life …

Normal ageing is associated with impairments in cognitive function, including memory.
These impairments are linked, not to a loss of neurons in the forebrain, but to specific and …

The prefrontal cortex (PFC) plays an important role in higher cognitive processes, and in the
regulation of stress-induced hypothalamic–pituitary–adrenal (HPA) activity. Here we …

Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder primarily
involving motoneurons. A subset of individuals with familial autosomal dominant forms of the …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which numerous
mouse models have been generated. In both AD patients and mouse models, there is …

In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol
has been doubted because of the inability to detect dehydroepiandrosterone synthase, …

Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic
regions of brain thought to be responsible for long-term behavioral plasticity driving addiction. …