We have disrupted the retinoid signalling pathway in adult rats by a dietary deficiency of
vitamin A. After 1 year of this dietary deficiency, there was a deposition of amyloid β in the …

Failure of axonal regeneration in the central nervous system (CNS) is mainly attributed to a
lack of intrinsic neuronal growth programs and an inhibitory environment from a glial scar. …

The retinoic acid receptor ( RAR ) α system plays a key role in the adult brain, participating
in the homeostatic control of synaptic plasticity, essential for memory function. Here we show …

Neuronal regeneration is a highly energy-demanding process that greatly relies on axonal
mitochondrial transport to meet the enhanced metabolic requirements. Mature neurons …

After spinal cord injury in the adult mammal, axons do not normally regrow and this commonly
leads to paralysis. Retinoic acid (RA) can stimulate neurite outgrowth in vitro of both the …

In the CNS, oligodendrocytes are responsible for myelin formation and maintenance.
Following spinal cord injury, oligodendrocyte loss and an inhibitory milieu compromise …

Stimulation of retinoic acid (RA) mediated signalling pathways following neural injury leads
to regeneration in the adult nervous system and numerous studies have shown that the …

By culturing neural progenitor cells in the presence of retinoid receptor agonists, we have
defined the components of the retinoid-signalling pathway that are important for the birth and …

Retinoic acid receptors (RARs) α, β, and γ are members of the nuclear receptor superfamily.
Compounds which bind to and activate the RARs are termed retinoids which regulate a …

Many studies have shown a role of retinoid signalling in neurite outgrowth in vitro, and that
the retinoic acid receptor (RAR) β2 is critical for this process. We show here that RARβ2 is …