A fundamental question in neuroscience concerns the relation between the spiking of
individual neurons and the aggregate electrical activity of neuronal ensembles as seen in local …

Grid cells in the entorhinal cortex appear to represent spatial location via a triangular coordinate
system. Such cells, which have been identified in rats, bats and monkeys, are believed …

In situ degradation of metal-alloy implants is undesirable for two reasons: the degradation
process may decrease the structural integrity of the implant, and the release of degradation …

Background Hereditary angioedema due to C1 inhibitor deficiency is characterized by
recurrent acute attacks of swelling that can be painful and sometimes life-threatening. Methods …

In many species, spatial navigation is supported by a network of place cells that exhibit
increased firing whenever an animal is in a certain region of an environment. Does this neural …

® Implant degradation products have been shown to be associated with dermatitis, urticaria,
and vasculitis. If cutaneous signs of an allergic response appear after implantation of a …

Background: The importance of particles generated by wear and corrosion of joint replacement
prostheses has been understood primarily in the context of the local effects of particle-…

Osteoarthritis is the most common form of arthritis, affecting millions of people in the United
States. It is a complex disease whose etiology bridges biomechanics and biochemistry. …

One hundred forty‐eight retrieved modular hip prostheses of both mixed (Ti‐6Al‐4V/CoCr)
and similar (CoCr/CoCr) metal combinations were examined and positive evidence of …

Porous tantalum, a new low modulus metal with a characteristic appearance similar to
cancellous bone, is currently available for use in several orthopedic applications (hip and knee …