Studies on the development of central nervous system (CNS) primarily rely on the use of
specific molecular markers for different types of neural cells. S100B is widely being used as a …

Myelin sheath formed by oligodendrocytes (OLs) is essential for the rapid propagation of
action potentials in the vertebrate CNS. Myelin regulatory factor (MYRF) is one of the critical …

Myelin sheathes ensure the rapid conduction of neural impulse and provide nutritional support
for neurons. Myelin sheathes are formed by differentiated oligodendrocytes (OLs) in the …

Caspase-3 is an attractive therapeutic target for treatment of diseases involving disregulated
apoptosis. We report here the mechanism of caspase-3 inactivation by isoquinoline-1,3,4-…

Side-chain modeling plays a critical role in protein structure prediction. However, in many
current methods, balancing the speed and accuracy is still challenging. In this paper, on the …

In the developing central nervous system, the terminal differentiation of oligodendrocytes (OLs)
is regulated by both extrinsic and intrinsic factors. Recent studies have suggested that …

Polycomb group (PcG) and Trithorax group (TrxG) proteins are essential for maintaining
epigenetic memory in both embryonic stem cells and differentiated cells. To date, how they are …

Aim: To discover novel cell division cycle 25 (CDC25) B inhibitors and elucidate the mechanisms
of inhibition in cancer cells. Methods: Cell growth inhibition was detected by MTT assay…

Notch signaling has been implicated in the inhibition of oligodendrocyte differentiation and
myelin gene expression during early development. However, inactivation of a particular …

. Caspase-1, the most efficient enzyme in processing the proinflammatory cytokines
interleukin 1β and interleukin 18 in humans, is associated with inflammatory diseases such as …