Neuronal signaling through endocytosis
KE Cosker, RA Segal - Cold Spring Harbor perspectives …, 2014 - cshperspectives.cshlp.org
The distinctive morphology of neurons, with complex dendritic arbors and extensive axons,
presents spatial challenges for intracellular signal transduction. The endosomal system …
presents spatial challenges for intracellular signal transduction. The endosomal system …
The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability
KE Cosker, SJ Fenstermacher, MF Pazyra-Murphy… - Nature …, 2016 - nature.com
To achieve accurate spatiotemporal patterns of gene expression, RNA-binding proteins (RBPs)
guide nuclear processing, intracellular trafficking and local translation of target mRNAs. …
guide nuclear processing, intracellular trafficking and local translation of target mRNAs. …
Action in the axon: generation and transport of signaling endosomes
KE Cosker, SL Courchesne, RA Segal - Current opinion in neurobiology, 2008 - Elsevier
Neurons extend axonal processes over long distances, necessitating efficient transport
mechanisms to convey target-derived neurotrophic survival signals from remote distal axons to …
mechanisms to convey target-derived neurotrophic survival signals from remote distal axons to …
Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration
KE Cosker, MF Pazyra-Murphy… - Journal of …, 2013 - Soc Neuroscience
Establishment of neuronal circuitry depends on both formation and refinement of neural
connections. During this process, target-derived neurotrophins regulate both transcription and …
connections. During this process, target-derived neurotrophins regulate both transcription and …
A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w
…, SL Courchesne, C Karch, KE Cosker… - Journal of …, 2009 - Soc Neuroscience
Survival and maturation of dorsal root ganglia sensory neurons during development depend
on target-derived neurotrophins. These target-derived signals must be transmitted across …
on target-derived neurotrophins. These target-derived signals must be transmitted across …
[PDF][PDF] Prolyl isomerase Pin1 regulates axon guidance by stabilizing CRMP2A selectively in distal axons
…, R Weissova, J Žiak, MF Pazyra-Murphy, KE Cosker… - Cell reports, 2015 - cell.com
Axon guidance relies on precise translation of extracellular signal gradients into local
changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent …
changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent …
Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis
KE Cosker, BJ Eickholt - Biochemical Society Transactions, 2007 - portlandpress.com
The establishment of neuronal morphology is essential for the formation of the nervous system.
In general, neurons undergo a developmental programme during which their immature …
In general, neurons undergo a developmental programme during which their immature …
Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPα during axonal extension in hippocampal neurons
KE Cosker, S Shadan, M Van Diepen… - Journal of cell …, 2008 - journals.biologists.com
… necessary for navigation toward appropriate targets (Cosker and Eickholt, 2007). One of the
best… K. Cosker is funded by a studentship from the Medical Research Council. The Cockcroft …
best… K. Cosker is funded by a studentship from the Medical Research Council. The Cockcroft …
[HTML][HTML] A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia
… K Cosker was supported by Eisai, working within the Eisai:UCL Therapeutic Innovation
Group (TIG). A Mallach was supported by the Biotechnology and Biological Sciences Research …
Group (TIG). A Mallach was supported by the Biotechnology and Biological Sciences Research …
[HTML][HTML] A payer perspective of the hospital inpatient additional care costs of antimicrobial resistance in France: a matched case–control study
…, M Opatowski, C Brun-Buisson, K Cosker… - … health economics and …, 2019 - Springer
Background and Objective Antimicrobial resistance (AMR) has become one of the biggest
threats to global public health given its association with mortality, morbidity and cost of health …
threats to global public health given its association with mortality, morbidity and cost of health …