… the subplate (Allendoerfer & Shatz … (Allendoerfer & Shatz 1 991). Moreover, the addition of
NGF to E30 ferret subplate neurons in culture does not enhance their survival (KL Allendoerfer …

Cell division, cell death, and remodeling of connections are major features of the construction
of the mammalian CNS. We have begun to address the role of neurotrophins in these …

Objective— The embryonic morphogen sonic hedgehog (SHh) has been shown to induce
neovascularization of ischemic tissue but has not been shown to play a role in regulating …

Hedgehog proteins modulate development and patterning of the embryonic nervous system.
As expression of desert hedgehog and the hedgehog receptor, patched-1, persist in the …

Neurotrophins play important roles in the survival, differentiation, and maintenance of CNS
neurons. To begin to investigate specific roles for these factors in the mammalian visual …

The construction of any nervous system from that of the simplest invertebrate to that of the
most complex mammal requires the solution of several major problems. Neurons must be …

Nerve growth factor and its receptor (NGFR) are known to be present in diverse embryonic
and neonatal central nervous system tissues, including the cerebral cortex. However, the …

In ventromedial cells of the developing CNS, Sonic hedgehog (Shh) has been shown to
affect precursor proliferation, phenotype determination, and survival. Here we show that Shh …

A key problem in nervous system development is how distinct subpopulations of progenitor
cells give rise to different adult brain structures. The labeling pattern of the FORSE-1 …

… Brains from embryonic and newborn rats were dissected and homogenized in PBS plus
protease inhibitors as described by Allendoerfer et al. (1995). The homogenates were …