Epigenetic genes and epilepsy—emerging mechanisms and clinical applications
KMJ Van Loo, GL Carvill, AJ Becker… - Nature Reviews …, 2022 - nature.com
An increasing number of epilepsies are being attributed to variants in genes with epigenetic
functions. The products of these genes include factors that regulate the structure and …
functions. The products of these genes include factors that regulate the structure and …
Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis
…, L Rolfes, L Wachsmuth, J Pitsch, KMJ van Loo… - Science …, 2023 - science.org
Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures,
progressive memory disturbance, and other behavioral and cognitive changes. CD8 T …
progressive memory disturbance, and other behavioral and cognitive changes. CD8 T …
[HTML][HTML] Transcriptional regulation of t-type calcium channel Cav3. 2
KMJ van Loo, C Schaub, K Pernhorst, Y Yaari… - Journal of Biological …, 2012 - ASBMB
The pore-forming Ca 2+ channel subunit Ca V 3.2 mediates a low voltage-activated (T-type)
Ca 2+ current (I CaT ) that contributes pivotally to neuronal and cardiac pacemaker activity. …
Ca 2+ current (I CaT ) that contributes pivotally to neuronal and cardiac pacemaker activity. …
DNA methylation-mediated modulation of endocytosis as potential mechanism for synaptic function regulation in murine inhibitory cortical interneurons
D Pensold, J Reichard, KMJ Van Loo… - Cerebral …, 2020 - academic.oup.com
The balance of excitation and inhibition is essential for cortical information processing, relying
on the tight orchestration of the underlying subcellular processes. Dynamic transcriptional …
on the tight orchestration of the underlying subcellular processes. Dynamic transcriptional …
[HTML][HTML] Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1
KMJ Van Loo, C Schaub, J Pitsch, R Kulbida… - Nature …, 2015 - nature.com
Temporal lobe epilepsy (TLE) is the most common focal seizure disorder in adults. In many
patients, transient brain insults, including status epilepticus (SE), are followed by a latent …
patients, transient brain insults, including status epilepticus (SE), are followed by a latent …
Identification of synaptotagmin 10 as effector of NPAS4-mediated protection from excitotoxic neurodegeneration
AMH Woitecki, JA Müller, KMJ van Loo… - Journal of …, 2016 - Soc Neuroscience
Neuronal degeneration represents a pathogenetic hallmark after different brain insults, such
as ischemia and status epilepticus (SE). Excessive release of glutamate triggered by …
as ischemia and status epilepticus (SE). Excessive release of glutamate triggered by …
CD8+ T‐Lymphocyte–Driven Limbic Encephalitis Results in Temporal Lobe Epilepsy
J Pitsch, KMJ van Loo, M Gallus, A Dik… - Annals of …, 2021 - Wiley Online Library
Objective Limbic encephalitis (LE) comprises a spectrum of inflammatory changes in affected
brain structures including the presence of autoantibodies and lymphoid cells. However, the …
brain structures including the presence of autoantibodies and lymphoid cells. However, the …
Heterogeneity and excitability of BRAFV600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss
S Cases-Cunillera, KMJ van Loo, J Pitsch… - Neuro …, 2022 - academic.oup.com
Background Developmental brain tumors harboring BRAF V600E somatic mutation are
diverse. Here, we describe molecular factors that determine BRAF V600E -induced tumor …
diverse. Here, we describe molecular factors that determine BRAF V600E -induced tumor …
[PDF][PDF] The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons
…, B Broske, A Mentani, A Wagener, KMJ van Loo… - Cell reports, 2021 - cell.com
Midbrain dopaminergic (mDA) neurons are diverse in their projection targets, effect on
behavior, and susceptibility to neurodegeneration. Little is known about the molecular …
behavior, and susceptibility to neurodegeneration. Little is known about the molecular …
Anti-epileptogenic and anti-convulsive effects of fingolimod in experimental temporal lobe epilepsy
…, JC Kuehn, V Gnatkovsky, JA Müller, KMJ van Loo… - Molecular …, 2019 - Springer
Temporal lobe epilepsy (TLE) represents a devastating neurological condition, in which
approximately 4/5 of patients remain refractory for anti-convulsive drugs. Epilepsy surgery …
approximately 4/5 of patients remain refractory for anti-convulsive drugs. Epilepsy surgery …