Spine growth and retraction with synapse formation and elimination plays an important role
in shaping brain circuits during development and in the adult brain, yet the temporal …

Recent electron microscopic studies provide evidence that the adult cortex generates new
synapses in response to sensory activity and that these structural changes can occur rapidly, …

The glutamatergic neuromuscular junction (NMJ) in Drosophila adds new boutons and
branches during larval development. We generated transgenic fruit flies that express a novel …

The elimination of dendritic spine synapses is a critical step in the refinement of neuronal
circuits during development of the cerebral cortex. Several studies have shown that activity-…

Previous studies have shown that both the Fasciclin II (Fas II) cell adhesion molecule and the
Shaker potassium channel are localized at the Drosophila neuromuscular junction, where …

Refinement of neural circuits in the mammalian cerebral cortex shapes brain function during
development and in the adult. However, the signaling mechanisms underlying the synapse-…

Competition between synapses contributes to activity-dependent refinement of the nervous
system during development. Does local competition between neighboring synapses drive …

Growth of new dendritic spines contributes to experience-dependent circuit plasticity in the
cerebral cortex. Yet the signaling mechanisms leading to new spine outgrowth remain poorly …

Learning new tasks has been associated with increased growth and stabilization of new
dendritic spines. We examined whether long-term potentiation (LTP), a key cellular mechanism …

In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic
membrane, where they act via Ca 2+ to signal coincidence detection in Hebbian plasticity. …