Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States
P Svenningsson, K Chergui, I Rachleff, M Flajolet… - Science, 2006 - science.org
The pathophysiology of depression remains enigmatic, although abnormalities in serotonin
signaling have been implicated. We have found that the serotonin 1B receptor [5-…
signaling have been implicated. We have found that the serotonin 1B receptor [5-…
Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity
…, B Picconi, G Bernardi, K Chergui… - Journal of …, 2000 - Soc Neuroscience
A complex chain of intracellular signaling events, critically important in motor control, is
activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At …
activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At …
The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons
L Arborelius, K Chergui, S Murase, GG Nomikos… - Naunyn-Schmiedeberg's …, 1993 - Springer
The effects of the selective 5-HT 1A receptor agonist (R)-8-hydroxy-2(di-n-propylamino)tetralin
[(R)-8-OH-DPAT] and the novel 5-HT 1A antagonist (S)-5-fluoro-8-hydroxy-2-(…
[(R)-8-OH-DPAT] and the novel 5-HT 1A antagonist (S)-5-fluoro-8-hydroxy-2-(…
Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum
K Chergui, P Svenningsson… - Proceedings of the …, 2004 - National Acad Sciences
Dopaminergic and glutamatergic neurotransmissions in the striatum play an essential role
in motor- and reward-related behaviors. Dysfunction of these neurotransmitter systems has …
in motor- and reward-related behaviors. Dysfunction of these neurotransmitter systems has …
GABAB receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo
Previous work demonstrates the fundamental role of the firing pattern, specifically the burst
firing mode of midbrain dopamine (DA) neurons in the regulation of DA release. …
firing mode of midbrain dopamine (DA) neurons in the regulation of DA release. …
Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors
K Chergui, H Akaoka, PJ Charléty, CF Saunier… - …, 1994 - journals.lww.com
: The role of the subthalamic nucleus in the burst firing of dopamine neurones of the substantia
nigra was investigated using extracellular single unit recordings combined with pressure …
nigra was investigated using extracellular single unit recordings combined with pressure …
Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens
SM Schotanus, K Chergui - Neuropharmacology, 2008 - Elsevier
Long-term changes in the efficacy of glutamatergic synaptic transmission in the striatal
complex are proposed to underlie motor learning and neuroadaptations leading to addiction. …
complex are proposed to underlie motor learning and neuroadaptations leading to addiction. …
[HTML][HTML] Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents
…, J Zareba-Paslawska, H Biverstål, K Chergui… - Nature …, 2023 - nature.com
Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked
to Parkinson’s disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post-…
to Parkinson’s disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post-…
Physiological role for casein kinase 1 in glutamatergic synaptic transmission
K Chergui, P Svenningsson… - Journal of …, 2005 - Soc Neuroscience
Casein kinase 1 (CK1) is a highly conserved serine/threonine kinase, present in virtually all
cell types, in which it phosphorylates a wide variety of substrates. So far, no role has been …
cell types, in which it phosphorylates a wide variety of substrates. So far, no role has been …
Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission
K Chergui, A Bouron, E Normand… - Journal of …, 2000 - Soc Neuroscience
Kainate receptors (KARs) are abundantly expressed in the basal ganglia, but their function
in synaptic transmission has not been established. In the present study, we show that the …
in synaptic transmission has not been established. In the present study, we show that the …