Because translational research is not clearly defined, developers of translational research
programs are struggling to articulate specific program objectives, delineate the knowledge …

The acute porphyrias, 4 inherited disorders of heme biosynthesis, cause life-threatening
attacks of neurovisceral symptoms that mimic many other acute medical and psychiatric …

The immune system operates as a diffuse sensory system, detecting the presence of specific
chemical constituents associated with dangerous micro-organisms, and then signalling the …

Inhalation of irritating substances leads to activation of the trigeminal nerve, triggering protective
reflexes that include apnea or sneezing. Receptors for trigeminal irritants are generally …

Background Up-regulation of hepatic delta-aminolevulinic acid synthase 1 (ALAS1), with
resultant accumulation of delta-aminolevulinic acid (ALA) and porphobilinogen, is central to the …

Soybean consumption is associated with reduced rates of breast, prostate, and colon cancer,
which is possibly related to the presence of isoflavones that are weakly estrogenic and …

The olfactory epithelium of fish contains three intermingled types of olfactory receptor neurons
(ORNs): ciliated, microvillous, and crypt. The present experiments were undertaken to test …

Background Erythropoietic protoporphyria is a severe photodermatosis that is associated
with acute phototoxicity. Patients with this condition have excruciating pain and a markedly …

The aim of this study was to determine if a change in protein/carbohydrate ratio influences
plasma steroid hormone concentrations. There is little information about the effects of specific …

Background Induction of delta aminolevulinic acid synthase 1 (ALAS1) gene expression
and accumulation of neurotoxic intermediates result in neurovisceral attacks and disease …