Calcium-activated potassium channels expressed from cloned complementary DNAs

JP Adelman, KZ Shen, MP Kavanaugh, RA Warren… - Neuron, 1992 - cell.com
Calcium-activated potassium channels were expressed in Xenopus oocytes by injection of
RNA transcribed in vitro from complementary DNAs derived from the s/o locus of Drosophila …

Synaptic plasticity in rat subthalamic nucleus induced by high‐frequency stimulation

KZ Shen, ZT Zhu, A Munhall, SW Johnson - Synapse, 2003 - Wiley Online Library
The technique of deep brain stimulation (DBS) has become a preferred surgical choice for
the treatment of advanced Parkinson's disease. The subthalamic nucleus (STN) is presently …

Presynaptic dopamine D2 and muscarine M3 receptors inhibit excitatory and inhibitory transmission to rat subthalamic neurones in vitro

KZ Shen, SW Johnson - The Journal of physiology, 2000 - Wiley Online Library
1 Whole‐cell patch‐clamp recordings were made from subthalamic nucleus (STN) neurones
in brain slices from rats. Stimulation with bipolar electrodes evoked synaptic currents …

[HTML][HTML] Functional differences among alternatively spliced variants of Slowpoke, a Drosophila calcium-activated potassium channel.

A Lagrutta, KZ Shen, RA North, JP Adelman - Journal of Biological …, 1994 - Elsevier
The Slowpoke locus of Drosophila melanogaster encodes a family of alternatively spliced
mRNAs which encode large conductance calcium-activated potassium channels. Variability …

Presynaptic GABAB and adenosine A1 receptors regulate synaptic transmission to rat substantia nigra reticulata neurones

KZ Shen, SW Johnson - The Journal of physiology, 1997 - Wiley Online Library
1 Patch pipettes were used to record whole‐cell currents under voltage clamp in substantia
nigra zona reticulata (SNR) neurones in the rat midbrain slice. Bipolar electrodes evoked …

Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro

KZ Shen, SW Johnson - The Journal of physiology, 2006 - Wiley Online Library
The subthalamic nucleus (STN) plays an important role in movement control by exerting its
excitatory influence on the substantia nigra pars reticulata (SNR), a major output structure of …

Dopamine depletion alters responses to glutamate and GABA in the rat subthalamic nucleus

KZ Shen, SW Johnson - Neuroreport, 2005 - journals.lww.com
We used whole-cell recordings to compare currents evoked by glutamate and GABA receptor
agonists in subthalamic nucleus neurons located ipsilateral and contralateral to unilateral 6…

Calcium‐dependent subthreshold oscillations determine bursting activity induced by N‐methyl‐d‐aspartate in rat subthalamic neurons in vitro

ZT Zhu, A Munhall, KZ Shen… - European Journal of …, 2004 - Wiley Online Library
We used whole‐cell patch recordings in current clamp to investigate the ionic dependence
of burst firing induced by N‐methyl‐d‐aspartate (NMDA) in neurons of the subthalamic …

Ca2+ Influx through NMDA-gated channels activates ATP-sensitive K+ currents through a nitric oxide–cGMP pathway in subthalamic neurons

KZ Shen, SW Johnson - Journal of Neuroscience, 2010 - Soc Neuroscience
Excessive burst firing of action potentials in subthalamic nucleus (STN) neurons has been
correlated with the bradykinesia and rigidity seen in Parkinson's disease. Consequently, there …

Presynaptic modulation of synaptic transmission by opioid receptor in rat subthalamic nucleus in vitro

KZ Shen, SW Johnson - The Journal of physiology, 2002 - Wiley Online Library
Presynaptic modulation of synaptic transmission in rat subthalamic nucleus (STN) neurons
was investigated using whole‐cell patch‐clamp recordings in brain slices. Evoked …