The cellular prion protein binds copper in vivo
The normal cellular form of prion protein (PrP C ) is a precursor to the pathogenic protease-resistant
forms (PrP Sc ) believed to cause scrapie, bovine spongiform encephalopathy (BSE) …
forms (PrP Sc ) believed to cause scrapie, bovine spongiform encephalopathy (BSE) …
Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann–Sträussler–Scheinker disease
CJ Cortes, K Qin, J Cook, A Solanki… - Journal of …, 2012 - Soc Neuroscience
Autophagy is a cell survival response to nutrient deprivation that delivers cellular components
to lysosomes for digestion. In recent years, autophagy has also been shown to assist in …
to lysosomes for digestion. In recent years, autophagy has also been shown to assist in …
[HTML][HTML] Mapping Cu (II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) …
K Qin, Y Yang, P Mastrangelo, D Westaway - Journal of Biological …, 2002 - ASBMB
Although Cu(II) ions bind to the prion protein (PrP), there have been conflicting findings
concerning the number and location of binding sites. We have combined diethyl pyrocarbonate (…
concerning the number and location of binding sites. We have combined diethyl pyrocarbonate (…
[HTML][HTML] Copper (II)-induced conformational changes and protease resistance in recombinant and cellular PrP: effect of protein age and deamidation
K Qin, DS Yang, Y Yang, MA Chishti, LJ Meng… - Journal of Biological …, 2000 - ASBMB
While PrP C rearranges in the area of codons 104–113 to form PrP Sc during prion infections,
the events that initiate sporadic Creutzfeldt-Jakob disease are undefined. As Cu(II) is a …
the events that initiate sporadic Creutzfeldt-Jakob disease are undefined. As Cu(II) is a …
Examining the zinc binding site of the amyloid‐β peptide
DS Yang, JA McLaurin, K Qin… - European Journal of …, 2000 - Wiley Online Library
The amyloid β‐peptide (Aβ) is a principal component of insoluble amyloid plaques which
are characteristic neuropathological features of Alzheimer's disease. Aβ also exists as a …
are characteristic neuropathological features of Alzheimer's disease. Aβ also exists as a …
[HTML][HTML] Doppel Is an N-Glycosylated, Glycosylphosphatidylinositol-anchored Protein: EXPRESSION IN TESTIS AND ECTOPIC PRODUCTION IN THE BRAINS …
GL Silverman, K Qin, RC Moore, Y Yang… - Journal of Biological …, 2000 - ASBMB
The Prnd gene encodes a homolog of the cellular prion protein (PrP C ) called doppel (Dpl).
Up-regulation of Prnd mRNA in two distinct lines of PrP gene ablated (Prnp 0/0 ) mice, …
Up-regulation of Prnd mRNA in two distinct lines of PrP gene ablated (Prnp 0/0 ) mice, …
Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro
L Li, J Liu, X Yan, K Qin, M Shi, T Lin, Y Zhu… - Journal of …, 2011 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng, a traditional Chinese herbal
medicine, has been widely used to restore the disease and enhance the healthy body in Asia …
medicine, has been widely used to restore the disease and enhance the healthy body in Asia …
[HTML][HTML] Generation of human chronic wasting disease in transgenic mice
Z Wang, K Qin, MV Camacho, I Cali, J Yuan… - Acta Neuropathologica …, 2021 - Springer
Chronic wasting disease (CWD) is a cervid prion disease caused by the accumulation of an
infectious misfolded conformer (PrP Sc ) of cellular prion protein (PrP C ). It has been …
infectious misfolded conformer (PrP Sc ) of cellular prion protein (PrP C ). It has been …
Ginsennoside rd attenuates cognitive dysfunction in a rat model of Alzheimer's disease
J Liu, X Yan, L Li, Y Zhu, K Qin, L Zhou, D Sun… - Neurochemical …, 2012 - Springer
Alzheimer’s disease is a neurodegenerative disease characterized by the production of β-amyloid
proteins and hyperphosphorylation of tau protein. Inflammation and apoptotic severity …
proteins and hyperphosphorylation of tau protein. Inflammation and apoptotic severity …
[HTML][HTML] ATM-mediated transcriptional elevation of prion in response to copper-induced oxidative stress
K Qin, L Zhao, RD Ash, WF McDonough… - Journal of biological …, 2009 - ASBMB
Increasing evidence suggests that the cellular prion protein (PrP C ) plays a protective role
in response to oxidative stress, but the molecular mechanism is unclear. Here, we …
in response to oxidative stress, but the molecular mechanism is unclear. Here, we …