User profiles for Keith M. Sharrow

Keith Sharrow

Chief, Bench Laboratory- DCI, William Beaumont Army Medical Center
Verified email at mail.mil
Cited by 1249

Calcineurin links Ca2+ dysregulation with brain aging

TC Foster, KM Sharrow, JR Masse… - Journal of …, 2001 - Soc Neuroscience
Brain aging is associated with altered Ca 2+ regulation. However, many Ca 2+ signal
transduction mechanisms have not been explored in the aged brain. Here, we report that cytosolic …

Interaction of age and chronic estradiol replacement on memory and markers of brain aging

TC Foster, KM Sharrow, A Kumar, J Masse - Neurobiology of aging, 2003 - Elsevier
The current study examined effects of chronic estradiol replacement on cognition and biomarkers
of aging. Young, middle-aged, and aged rats were ovariectomized and implanted with …

Calcineurin as a potential contributor in estradiol regulation of hippocampal synaptic function

KM Sharrow, A Kumar, TC Foster - Neuroscience, 2002 - Elsevier
Estradiol influences Ca 2+ regulation and Ca 2+ -dependent synaptic plasticity, suggesting
estrogenic effects on Ca 2+ -dependent enzymes that regulate synaptic plasticity may …

Recovery from ischemic brain injury in the rat following a 10 h delayed injection with MLN519

AJ Williams, TM Myers, SI Cohn, KM Sharrow… - Pharmacology …, 2005 - Elsevier
In the present study, we evaluated delayed treatment effects of the proteasome inhibitor and
anti-inflammatory agent MLN519 (initiated 10 h post-injury) to improve recovery following …

[BOOK][B] Acute estrogen (17B-estradiol) treatments ameliorate molecular and behavioral biomarkers of brain aging

KM Sharrow - 2002 - search.proquest.com
… By Keith Michael Sharrow … My mom and dad, Elizabeth and James Sharrow, for always
pushing me to go further and to never settle for second best. I am starting to understand, …

Cell surface antigenic characteristics of rat large granular lymphocytes (LGL)

…, T Barlozzari, RB Herberman, SO Sharrow… - NK Cells and Other …, 1982 - Elsevier
Publisher Summary This chapter examines cell-surface antigenic characteristics of rat large
granular lymphocytes (LGL). LGL have distinct azurophilic granules in their cytoplasm and …

Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment

EM Blalock, KC Chen, K Sharrow… - Journal of …, 2003 - Soc Neuroscience
Gene expression microarrays provide a powerful new tool for studying complex processes
such as brain aging. However, inferences from microarray data are often hindered by multiple …

Lymphokine-activated killer cell phenomenon. II. Precursor phenotype is serologically distinct from peripheral T lymphocytes, memory cytotoxic thymus-derived …

EA Grimm, KM Ramsey, A Mazumder… - The Journal of …, 1983 - rupress.org
Culture of human peripheral blood lymphocytes (PBL) in partially purified and lectin-free
interleukin 2 results in the generation of cytotoxic effector cells which have the unique property …

[BOOK][B] NK cells and other natural effector cells

RB Herberman - 2012 - books.google.com
Sharrow, Keith M. Ramsey, K0 Okumura, and Sonoko Habu … The Relation between Human
Natural Killer Cells and Interleukin-2 Wolfgang Domzig and Redo M. Stadler Modulation of …

Recovery from and consequences of severe iatrogenic lymphopenia (induced to treat autoimmune diseases)

…, Y Akatsuka, MD Metcalf, H Lu, T Kalina, M Reindl… - Clinical …, 2004 - Elsevier
To ascertain the consequences of severe leukopenia and the tempo of recovery, we studied
the immunity of 56 adult patients treated for multiple sclerosis or systemic sclerosis with …