The melanocortin-4 receptor (MC4R) is critically involved in regulating energy balance, and
obesity has been observed in mice with mutations in the gene for brain-derived neurotrophic …

trkB encodes a receptor tyrosine kinase activated by three neurotrophins—brain-derived
neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5. In vivo, three isoforms of the …

Lung cancer is the leading cause of cancer death in the world, but the molecular mechanisms
for its development have not been well characterized. The suppressors of cytokine …

The neurotrophin BDNF has been shown to modulate long-term potentiation (LTP) at
Schaffer collateral-CA1 hippocampal synapses. Mutants in the BDNF receptor gene trkB and …

To examine functions of TrkB in the adult CNS, TrkB has been removed from neurons expressing
CaMKII, primarily pyramidal neurons, using Cre-mediated recombination. A floxed trkB …

In order to assess the in vivo function of integrins containing the β8 subunit, we have generated
integrin β8-deficient mice. Ablation of β8 results in embryonic or perinatal lethality with …

Targeted deletion of focal adhesion kinase (fak) in the developing dorsal forebrain resulted
in local disruptions of the cortical basement membrane located between the neuroepithelium …

Both the cadherin-catenin complex and Rho-family GTPases have been shown to regulate
dendrite development. We show here a role for p120 catenin (p120ctn) in regulating spine …

We showed previously that loss of the integrin β8 subunit, which forms αvβ8 heterodimers,
results in abnormal vascular development in the yolk sac, placenta, and brain. Animals …

Integrins are a large family of cell adhesion receptors involved in a variety of cellular functions.
To study their roles at central synapses, we used two cre recombinase lines to delete the …