[PDF][PDF] Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel

L Zhong, A Bellemer, H Yan, K Honjo, J Robertson… - Cell reports, 2012 - cell.com
Specialized somatosensory neurons detect temperatures ranging from pleasantly cool or
warm to burning hot and painful (nociceptive). The precise temperature ranges sensed by …

Distinctive neuronal networks and biochemical pathways for appetitive and aversive memory in Drosophila larvae

K Honjo, K Furukubo-Tokunaga - Journal of Neuroscience, 2009 - Soc Neuroscience
Associative strength between conditioned stimulus (CS) and unconditioned stimulus (US) is
thought to determine learning efficacy in classical conditioning. Elucidation of the neuronal …

Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly

…, Y Maruyama, M Fujimuro, H Mochizuki, K Honjo… - Molecular …, 2008 - nature.com
Disrupted-in-schizophrenia-1 (DISC1) is one of major susceptibility factors for a wide range
of mental illnesses, including schizophrenia, bipolar disorder, major depression and autism …

Nociceptive interneurons control modular motor pathways to promote escape behavior in Drosophila

A Burgos, K Honjo, T Ohyama, CS Qian, GJ Shin… - Elife, 2018 - elifesciences.org
10.7554/eLife.26016.001 Rapid and efficient escape behaviors in response to noxious sensory
stimuli are essential for protection and survival. Yet, how noxious stimuli are transformed …

[PDF][PDF] Nociceptor-enriched genes required for normal thermal nociception

K Honjo, SE Mauthner, Y Wang, JHP Skene… - Cell reports, 2016 - cell.com
Here, we describe a targeted reverse genetic screen for thermal nociception genes in
Drosophila larvae. Using laser capture microdissection and microarray analyses of nociceptive …

[PDF][PDF] Balboa binds to pickpocket in vivo and is required for mechanical nociception in Drosophila larvae

…, AH Lewis, Q Xiao, A Tsubouchi, Y Wang, K Honjo… - Current Biology, 2014 - cell.com
The Drosophila gene pickpocket (ppk) encodes an ion channel subunit of the degenerin/epithelial
sodium channel (DEG/ENaC) family [1]. PPK is specifically expressed in nociceptive, …

Induction of cAMP response element-binding protein-dependent medium-term memory by appetitive gustatory reinforcement in Drosophila larvae

K Honjo, K Furukubo-Tokunaga - Journal of Neuroscience, 2005 - Soc Neuroscience
The fruit fly Drosophila melanogaster has been successfully used as a model animal for the
study of the genetic and molecular mechanisms of learning and memory. Although most of …

[HTML][HTML] Large expert-curated database for benchmarking document similarity detection in biomedical literature search

…, D Widera, J Zhang, A Meule, K Honjo… - Database, 2019 - academic.oup.com
Document recommendation systems for locating relevant literature have mostly relied on
methods developed a decade ago. This is largely due to the lack of a large offline gold-…

Optogenetic manipulation of neural circuits and behavior in Drosophila larvae

K Honjo, RY Hwang, WD Tracey Jr - Nature protocols, 2012 - nature.com
Optogenetics is a powerful tool that enables the spatiotemporal control of neuronal activity
and circuits in behaving animals. Here, we describe our protocol for optical activation of …

A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila

…, H Tanimoto, K Furukubo-Tokunaga, K Honjo - Elife, 2023 - elifesciences.org
Nociception is a neural process that animals have developed to avoid potentially tissuedamaging
stimuli. While nociception is triggered in the peripheral nervous system, its modulation …