User profiles for Kirk Mykytyn

Kirk Mykytyn

Associate Professor of Pharmacology, Ohio State University
Verified email at osu.edu
Cited by 5503

Cellular signalling by primary cilia in development, organ function and disease

Z Anvarian, K Mykytyn, S Mukhopadhyay… - Nature Reviews …, 2019 - nature.com
Primary cilia project in a single copy from the surface of most vertebrate cell types; they detect
and transmit extracellular cues to regulate diverse cellular processes during development …

Bardet–Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

…, GA Bishop, CC Askwith, K Mykytyn - Proceedings of the …, 2008 - National Acad Sciences
Primary cilia are ubiquitous cellular appendages that provide important yet not well understood
sensory and signaling functions. Ciliary dysfunction underlies numerous human genetic …

Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome

K Mykytyn, DY Nishimura, CC Searby, M Shastri… - Nature …, 2002 - nature.com
Bardet-Biedl syndrome (BBS, OMIM 209900) is a genetic disorder with the primary features
of obesity, pigmentary retinopathy, polydactyly, renal malformations, mental retardation and …

Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin

…, R Davis, JL Andorf, K Mykytyn… - Proceedings of the …, 2004 - National Acad Sciences
Bardet–Biedl syndrome (BBS) is a heterogeneous, pleiotropic human disorder characterized
by obesity, retinopathy, polydactyly, renal and cardiac malformations, learning disabilities, …

Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors

…, JS Lewis, CC Askwith, K Mykytyn - Molecular biology of …, 2008 - Am Soc Cell Biol
Primary cilia are sensory organelles present on most mammalian cells. The functions of cilia
are defined by the signaling proteins localized to the ciliary membrane. Certain G protein–…

Bardet–Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly

K Mykytyn, RF Mullins, M Andrews… - Proceedings of the …, 2004 - National Acad Sciences
The functions of the proteins encoded by the Bardet–Biedl syndrome (BBS) genes are
unknown. Mutations in these genes lead to the pleiotropic human disorder BBS, which is …

Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain

…, NF Berbari, J Lewis, K Mykytyn - Journal of Comparative …, 2007 - Wiley Online Library
Solitary primary cilia project from nearly every cell type in the human body. These organelles
are considered to have important sensory and signaling functions. Although primary cilia …

Identification of the gene that, when mutated, causes the human obesity syndrome BBS4

K Mykytyn, T Braun, R Carmi, NB Haider, CC Searby… - Nature …, 2001 - nature.com
Bardet–Biedl syndrome (BBS, MIM 209900) is a heterogeneous autosomal recessive
disorder characterized by obesity, pigmentary retinopathy, polydactyly, renal malformations, …

Mutations in MKKS cause Bardet-Biedl syndrome

AM Slavotinek, EM Stone, K Mykytyn, JR Heckenlively… - Nature …, 2000 - nature.com
Bardet-Biedl syndrome (BBS) is an autosomal recessive disorder with locus heterogeneity 5,
6, 7, 8, 9. None of the ‘responsible’genes have previously been identified. Some BBS …

Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins

…, KG Lee, AD Johnson, CC Askwith, K Mykytyn - Cellular and Molecular …, 2011 - Springer
Primary cilia are nearly ubiquitous cellular appendages that provide important sensory and
signaling functions. Ciliary dysfunction underlies numerous human diseases, collectively …