User profiles for Kirk Mykytyn
Kirk MykytynAssociate Professor of Pharmacology, Ohio State University Verified email at osu.edu Cited by 5503 |
Cellular signalling by primary cilia in development, organ function and disease
Z Anvarian, K Mykytyn, S Mukhopadhyay… - Nature Reviews …, 2019 - nature.com
Primary cilia project in a single copy from the surface of most vertebrate cell types; they detect
and transmit extracellular cues to regulate diverse cellular processes during development …
and transmit extracellular cues to regulate diverse cellular processes during development …
Bardet–Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia
Primary cilia are ubiquitous cellular appendages that provide important yet not well understood
sensory and signaling functions. Ciliary dysfunction underlies numerous human genetic …
sensory and signaling functions. Ciliary dysfunction underlies numerous human genetic …
Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome
K Mykytyn, DY Nishimura, CC Searby, M Shastri… - Nature …, 2002 - nature.com
Bardet-Biedl syndrome (BBS, OMIM 209900) is a genetic disorder with the primary features
of obesity, pigmentary retinopathy, polydactyly, renal malformations, mental retardation and …
of obesity, pigmentary retinopathy, polydactyly, renal malformations, mental retardation and …
Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin
Bardet–Biedl syndrome (BBS) is a heterogeneous, pleiotropic human disorder characterized
by obesity, retinopathy, polydactyly, renal and cardiac malformations, learning disabilities, …
by obesity, retinopathy, polydactyly, renal and cardiac malformations, learning disabilities, …
Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors
…, JS Lewis, CC Askwith, K Mykytyn - Molecular biology of …, 2008 - Am Soc Cell Biol
Primary cilia are sensory organelles present on most mammalian cells. The functions of cilia
are defined by the signaling proteins localized to the ciliary membrane. Certain G protein–…
are defined by the signaling proteins localized to the ciliary membrane. Certain G protein–…
Bardet–Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly
K Mykytyn, RF Mullins, M Andrews… - Proceedings of the …, 2004 - National Acad Sciences
The functions of the proteins encoded by the Bardet–Biedl syndrome (BBS) genes are
unknown. Mutations in these genes lead to the pleiotropic human disorder BBS, which is …
unknown. Mutations in these genes lead to the pleiotropic human disorder BBS, which is …
Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain
…, NF Berbari, J Lewis, K Mykytyn - Journal of Comparative …, 2007 - Wiley Online Library
Solitary primary cilia project from nearly every cell type in the human body. These organelles
are considered to have important sensory and signaling functions. Although primary cilia …
are considered to have important sensory and signaling functions. Although primary cilia …
Identification of the gene that, when mutated, causes the human obesity syndrome BBS4
Bardet–Biedl syndrome (BBS, MIM 209900) is a heterogeneous autosomal recessive
disorder characterized by obesity, pigmentary retinopathy, polydactyly, renal malformations, …
disorder characterized by obesity, pigmentary retinopathy, polydactyly, renal malformations, …
Mutations in MKKS cause Bardet-Biedl syndrome
Bardet-Biedl syndrome (BBS) is an autosomal recessive disorder with locus heterogeneity 5,
6, 7, 8, 9. None of the ‘responsible’genes have previously been identified. Some BBS …
6, 7, 8, 9. None of the ‘responsible’genes have previously been identified. Some BBS …
Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins
Primary cilia are nearly ubiquitous cellular appendages that provide important sensory and
signaling functions. Ciliary dysfunction underlies numerous human diseases, collectively …
signaling functions. Ciliary dysfunction underlies numerous human diseases, collectively …