Dysregulated metabolism of the amyloid‐β protein and therapeutic approaches in Alzheimer disease

K Kikuchi, K Kidana, T Tatebe… - Journal of Cellular …, 2017 - Wiley Online Library
Amyloid‐β protein (Aβ) is the main component of senile plaques in the brains of Alzheimer
disease (AD) patients. Aβ is proteolytically derived from amyloid‐β precursor protein by β‐ …

Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

K Kidana, T Tatebe, K Ito, N Hara, A Kakita… - EMBO Molecular …, 2018 - embopress.org
Deposition of amyloid‐β (Aβ) as senile plaques is one of the pathological hallmarks in the
brains of Alzheimer's disease ( AD ) patients. In addition, glial activation has been found in AD …

Changes in polypharmacy and potentially inappropriate medications in homebound older adults in Japan, 2015–2019: a Nationwide study

…, M Iwagami, N Sakata, Y Hattori, K Kidana… - Journal of General …, 2023 - Springer
Background With rising worldwide population aging, the number of homebound individuals
with multimorbidity is increasing. Improvement in the quality of home medical care (HMC), …

GPR120 signaling controls amyloid-β degrading activity of matrix metalloproteinases

…, T Tatebe, Y Sudo, M Yokoyama, K Kidana… - Journal of …, 2021 - Soc Neuroscience
Alzheimer's disease (AD) is characterized by the extensive deposition of amyloid-β peptide (Aβ)
in the brain. Brain Aβ level is regulated by a balance between Aβ production and …

Cognitive function has a stronger correlation with perceived age than with chronological age

…, T Kojima, M Ishii, K Kidana… - Geriatrics & …, 2020 - Wiley Online Library
Aim The perceived age of older adults, as measured by their facial appearance, has been
shown to be a robust biomarker of aging predictive of survival, telomere length and DNA …

Drug prescribing changes in the last year of life among homebound older adults: national retrospective cohort study

…, S Hamada, T Yamanaka, K Kidana… - BMJ Supportive & …, 2023 - spcare.bmj.com
Objectives This study aimed to evaluate the prescription patterns of drugs during the last
year of life in homebound older adults who received home medical care. Methods We used a …

Palliative home care for older patients with respiratory disease in Japan: Practices and opinions of physicians

T Yamanaka, K Kidana, Y Yamaguchi… - Geriatrics & …, 2022 - Wiley Online Library
Aim Older adults at the end‐of‐life stage receiving home visits from physicians often
experience symptoms such as dyspnea, pain and fatigue, among others. This study aimed to …

Medication prescription in older people receiving home medical care services.

K Kidana, S Ishii, I Osawa, A Yoneda… - Geriatrics & …, 2019 - search.ebscohost.com
The article focuses on medication prescription in older people who receive home medical
care services. Topics include investigation of poly-pharmacy occurrence among older patients …

Characteristics and Prognoses of Long-Term Home Care Patients

T Yamanaka, M Mizuki, K Kidana, R Yamaga - Innovation in Aging, 2021 - ncbi.nlm.nih.gov
With demographic aging, many older adults require home medical care. Although home-based
primary care is promoted in the United States and Japan, there is insufficient evidence …

Association of hearing loss with behavioral and psychological symptoms in patients with dementia.

…, K Iijima, K Yamaguchi, K Kidana… - Geriatrics & …, 2014 - search.ebscohost.com
The author discusses a study which determined whether hearing loss has adverse influence
on behavioral and psychological symptoms of dementia (BPSD). It references a study by S. …