Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.

E Ito, K Oka, R Etcheberrigaray… - Proceedings of the …, 1994 - National Acad Sciences
The recent demonstration of K+ channel dysfunction in fibroblasts from Alzheimer disease (AD)
patients and past observations of Ca(2+)-mediated K+ channel modulation during …

A web‐based interactive developmental table for the ascidian Ciona intestinalis, including 3D real‐image embryo reconstructions: I. From fertilized egg to hatching …

…, H Takahashi, K Inaba, K Oka… - … dynamics: an official …, 2007 - Wiley Online Library
The ascidian chordate Ciona intestinalis is an established model organism frequently exploited
to examine cellular development and a rapidly emerging model organism with a strong …

Single Molecular Multianalyte (Ca2+, Mg2+) Fluorescent Probe and Applications to Bioimaging

…, T Kubota, Y Shindo, Y Kitamura, K Oka… - Journal of the …, 2005 - ACS Publications
Intracellular signal transduction relies on spatial and temporal signal transmitter dynamics.
To clarify the correlations of these transmitter molecules, multicolor-imaging has been widely …

Design and Synthesis of Highly Sensitive and Selective Fluorescein-Derived Magnesium Fluorescent Probes and Application to Intracellular 3D Mg2+ Imaging

…, T Kubota, K Tokuno, Y Kitamura, K Oka… - Journal of the …, 2004 - ACS Publications
The role of intracellular magnesium ions is of high interest in the fields of pharmacology and
cellular biology. To accomplish the dynamic and three-dimensional imaging of intracellular …

Inhibition of RANKL‐induced osteoclastogenesis by (−)‐DHMEQ, a novel NF‐κB inhibitor, through downregulation of NFATc1

H Takatsuna, M Asagiri, T Kubota, K Oka… - Journal of Bone and …, 2005 - academic.oup.com
(−)‐DHMEQ, a newly designed NF‐κB inhibitor, inhibited RANKL‐induced osteoclast
differentiation in mouse BMMs through downregulation of the induction of NFATc1, an essential …

[PDF][PDF] A transient rise in free Mg2+ ions released from ATP-Mg hydrolysis contributes to mitotic chromosome condensation

…, S Kawakami, R Nagashima, T Soga, H Noji, K Oka… - Current Biology, 2018 - cell.com
For cell division, negatively charged chromatin, in which nucleosome fibers (10 nm fibers)
are irregularly folded [1–5], must be condensed into chromosomes and segregated. While …

[HTML][HTML] Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress

…, Y Shindo, K Hotta, K Suzuki, T Soga, K Oka - Scientific reports, 2016 - nature.com
Cellular energy production processes are composed of many Mg 2+ dependent enzymatic
reactions. In fact, dysregulation of Mg 2+ homeostasis is involved in various cellular …

[HTML][HTML] Simultaneous live cell imaging using dual FRET sensors with a single excitation light

Y Niino, K Hotta, K Oka - PloS one, 2009 - journals.plos.org
Fluorescence resonance energy transfer (FRET) between fluorescent proteins is a powerful
tool for visualization of signal transduction in living cells, and recently, some strategies for …

Design and Synthesis of Mg2+-Selective Fluoroionophores Based on a Coumarin Derivative and Application for Mg2+ Measurement in a Living Cell

…, Y Kitamura, T Kubota, J Nakagawa, K Oka… - Analytical …, 2002 - ACS Publications
Novel Mg 2+ fluorescent molecular probes (KMG-20-AM and KMG-27-AM; where AM is an
acetoxymethyl group) based on a coumarin possessing a charged β-diketone structure were …

[HTML][HTML] Magnesium is a key player in neuronal maturation and neuropathology

R Yamanaka, Y Shindo, K Oka - International journal of molecular …, 2019 - mdpi.com
Magnesium (Mg) is the second most abundant cation in mammalian cells, and it is essential
for numerous cellular processes including enzymatic reactions, ion channel functions, …