Protein phosphatase 1 regulates the histone code for long-term memory
K Koshibu, J Gräff, M Beullens, FD Heitz… - Journal of …, 2009 - Soc Neuroscience
Chromatin remodeling through histone posttranslational modifications (PTMs) and DNA
methylation has recently been implicated in cognitive functions, but the mechanisms involved in …
methylation has recently been implicated in cognitive functions, but the mechanisms involved in …
Control of the establishment of aversive memory by calcineurin and Zif268
…, H Welzl, RY Tweedie-Cullen, K Koshibu… - Nature …, 2008 - nature.com
Emotional memory is a rapidly acquired and persistent form of memory, and its robustness is
in part determined by the initial strength of the memory. Here, we provide new evidence that …
in part determined by the initial strength of the memory. Here, we provide new evidence that …
[HTML][HTML] The A2 subunit of factor VIIIa modulates the active site of factor IXa
PJ Fay, K Koshibu - Journal of Biological Chemistry, 1998 - ASBMB
Factor VIIIa, the protein cofactor for factor IXa, is comprised of A1, A2, and A3-C1-C2 subunits.
Isolated subunits of factor VIIIa were examined for their ability to accelerate the factor IXa-…
Isolated subunits of factor VIIIa were examined for their ability to accelerate the factor IXa-…
Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity
J Gräff, K Koshibu, A Jouvenceau, P Dutar… - Learning & …, 2010 - learnmem.cshlp.org
Gene transcription is essential for the establishment and the maintenance of long-term
memory (LTM) and for long-lasting forms of synaptic plasticity. The molecular mechanisms that …
memory (LTM) and for long-lasting forms of synaptic plasticity. The molecular mechanisms that …
Sex-specific, postpuberty changes in mouse brain structures revealed by three-dimensional magnetic resonance microscopy
Sexual dimorphism of brain structures has been reported in some species. We report that
sex-dependent developmental structure changes exist in the C57Bl/6 J mouse, a common …
sex-dependent developmental structure changes exist in the C57Bl/6 J mouse, a common …
[HTML][HTML] Effects of natural monoamine oxidase inhibitors on anxiety-like behavior in zebrafish
…, A Alzualde, MC Peitsch, J Hoeng, K Koshibu - Frontiers in …, 2021 - frontiersin.org
Monoamine oxidases (MAO) are a valuable class of mitochondrial enzymes with a critical
role in neuromodulation. In this study, we investigated the effect of natural MAO inhibitors on …
role in neuromodulation. In this study, we investigated the effect of natural MAO inhibitors on …
[HTML][HTML] Differential effects of alkaloids on memory in rodents
…, AV Terry Jr, MC Peitsch, J Hoeng, K Koshibu - Scientific reports, 2021 - nature.com
Nicotinic acetylcholine receptors (nAChRs) play a critical role in the neuropharmacology of
learning and memory. As such, naturally occurring alkaloids that regulate nAChR activity …
learning and memory. As such, naturally occurring alkaloids that regulate nAChR activity …
Inducible and neuron‐specific gene expression in the adult mouse brain with the rtTA2S‐M2 system
A Michalon, K Koshibu, K Baumgärtel, DH Spirig… - genesis, 2005 - Wiley Online Library
To achieve inducible and reversible gene expression in the adult mouse brain, we exploited
an improved version of the tetracycline‐controlled transactivator‐based system (rtTA2 S ‐M2…
an improved version of the tetracycline‐controlled transactivator‐based system (rtTA2 S ‐M2…
[HTML][HTML] Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products
M van der Toorn, K Koshibu, WK Schlage, S Majeed… - Toxicology Reports, 2019 - Elsevier
The adverse effects of cigarette smoking are well documented, and the two main strategies
for reducing smoking prevalence are prevention of smoking initiation and promotion of …
for reducing smoking prevalence are prevention of smoking initiation and promotion of …
Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brain
GF Hédou, K Koshibu, M Farinelli, E Kilic… - Journal of …, 2008 - Soc Neuroscience
Protein kinases and phosphatases can alter the impact of excitotoxicity resulting from
ischemia by concurrently modulating apoptotic/survival pathways. Here, we show that protein …
ischemia by concurrently modulating apoptotic/survival pathways. Here, we show that protein …