The physiology of mechanoelectrical transduction channels in hearing
R Fettiplace, KX Kim - Physiological reviews, 2014 - journals.physiology.org
Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …
Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses
KX Kim, S Payne, A Yang-Hood, SZ Li… - Journal of …, 2019 - Soc Neuroscience
Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic
mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is …
mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is …
Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel–like proteins
KX Kim, R Fettiplace - Journal of General Physiology, 2013 - rupress.org
Vibration of the stereociliary bundles activates calcium-permeable mechanotransducer (MT)
channels to initiate sound detection in cochlear hair cells. Different regions of the cochlea …
channels to initiate sound detection in cochlear hair cells. Different regions of the cochlea …
Maturation of NaV and KV channel topographies in the auditory nerve spike initiator before and after developmental onset of hearing function
KX Kim, MA Rutherford - Journal of Neuroscience, 2016 - Soc Neuroscience
Auditory nerve excitation and thus hearing depend on spike-generating ion channels and
their placement along the axons of auditory nerve fibers (ANFs). The developmental …
their placement along the axons of auditory nerve fibers (ANFs). The developmental …
The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels
KX Kim, M Beurg, CM Hackney, DN Furness… - Journal of General …, 2013 - rupress.org
Sound stimuli elicit movement of the stereocilia that make up the hair bundle of cochlear
hair cells, putting tension on the tip links connecting the stereocilia and thereby opening …
hair cells, putting tension on the tip links connecting the stereocilia and thereby opening …
Conductance and block of hair-cell mechanotransducer channels in transmembrane channel–like protein mutants
M Beurg, KX Kim, R Fettiplace - Journal of General Physiology, 2014 - rupress.org
Transmembrane channel–like (TMC) proteins TMC1 and TMC2 are crucial to the function of
the mechanotransducer (MT) channel of inner ear hair cells, but their precise function has …
the mechanotransducer (MT) channel of inner ear hair cells, but their precise function has …
Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium
SH Kim, KX Kim, NN Raveendran… - … of Physiology-Cell …, 2009 - journals.physiology.org
Reissner's membrane epithelium forms much of the barrier that produces and sustains the
large ionic differences between cochlear endolymph and perilymph. We have reported that …
large ionic differences between cochlear endolymph and perilymph. We have reported that …
Impaired Speaking-Induced Suppression in Alzheimer's Disease
Alzheimer’s disease (AD) is a neurodegenerative disease involving cognitive impairment
and abnormalities in speech and language. Here, we examine how AD affects the fidelity of …
and abnormalities in speech and language. Here, we examine how AD affects the fidelity of …
[HTML][HTML] Slc26a7 chloride channel activity and localization in mouse Reissner's membrane epithelium
KX Kim, JD Sanneman, HM Kim, DG Harbidge, J Xu… - PLoS …, 2014 - journals.plos.org
Several members of the SLC26 gene family have highly-restricted expression patterns in
the auditory and vestibular periphery and mutations in mice of at least two of these (SLC26A4 …
the auditory and vestibular periphery and mutations in mice of at least two of these (SLC26A4 …
Inward-rectifier chloride currents in Reissner's membrane epithelial cells
KX Kim, DC Marcus - Biochemical and biophysical research …, 2010 - Elsevier
Sensory transduction in the cochlea depends on regulated ion secretion and absorption.
Results of whole-organ experiments suggested that Reissner’s membrane may play a role in …
Results of whole-organ experiments suggested that Reissner’s membrane may play a role in …