User profiles for L. Coutellier

Laurence Coutellier

The Ohio State University
Verified email at osu.edu
Cited by 1880

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: evidence for over-inhibition

CE Page, L Coutellier - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

Sex differences in risk and resilience: stress effects on the neural substrates of emotion and motivation

…, DA Bangasser, JL Bollinger, L Coutellier… - Journal of …, 2018 - Soc Neuroscience
Risk for stress-sensitive psychopathologies differs in men and women, yet little is known about
sex-dependent effects of stress on cellular structure and function in corticolimbic regions …

A dramatic increase of C1q protein in the CNS during normal aging

…, DA Fraser, EA Lovelett, L Coutellier, L Kim… - Journal of …, 2013 - Soc Neuroscience
L, M, C1q immunoreactivity dramatically increased with age in synaptic layers of the human
hippocampus. L, C1q immunoreactivity in the human infant (2-month-old) was restricted to …

Age-and sex-specific effects of stress on parvalbumin interneurons in preclinical models: Relevance to sex differences in clinical neuropsychiatric and …

EM Woodward, L Coutellier - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Stress is a major risk factor for neurodevelopmental and neuropsychiatric disorders, with the
capacity to impact susceptibility to disease as well as long-term neurobiological and …

Pig's responses to repeated social regrouping and relocation during the growing-finishing period

L Coutellier, C Arnould, A Boissy, P Orgeur… - Applied animal …, 2007 - Elsevier
In animal husbandry, pigs have to cope with social challenges when regrouped with unfamiliar
conspecifics. Regrouping pigs may result in an acute stress and physical injuries thus …

[HTML][HTML] Npas4: a neuronal transcription factor with a key role in social and cognitive functions relevant to developmental disorders

L Coutellier, S Beraki, PM Ardestani, NL Saw… - 2012 - journals.plos.org
Npas4 is a transcription factor, which is highly expressed in the brain and regulates the
formation and maintenance of inhibitory synapses in response to excitatory synaptic activity. A …

Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: relevance for sex differences in stress-related disorders

R Shepard, CE Page, L Coutellier - Neuroscience, 2016 - Elsevier
Stress-induced modifications of the prefrontal cortex (PFC) are believed to contribute to the
onset of mood disorders, such as depression and anxiety, which are more prevalent in …

Changes in the prefrontal glutamatergic and parvalbumin systems of mice exposed to unpredictable chronic stress

R Shepard, L Coutellier - Molecular neurobiology, 2018 - Springer
The prefrontal cortex (PFC) is highly sensitive to the effects of stress, a known risk factor of
mood disorders including anxiety and depression. Abnormalities in PFC functioning have …

[HTML][HTML] Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice

CE Page, R Shepard, K Heslin, L Coutellier - Scientific reports, 2019 - nature.com
Reduced activity of the prefrontal cortex (PFC) is seen in mood disorders including depression
and anxiety. The mechanisms of this hypofrontality remain unclear. Because of their …

Adolescent stress disrupts the maturation of anxiety-related behaviors and alters the developmental trajectory of the prefrontal cortex in a sex-and age-specific manner

CE Page, L Coutellier - Neuroscience, 2018 - Elsevier
Adolescence is a window of vulnerability to environmental factors such as chronic stress that
can disrupt brain development and cause long-lasting behavioral dysfunction, as seen in …