KDR kinase inhibition is considered to play an important role in regulating angiogenesis,
which is vital for the survival and proliferation of tumor cells. Recently we disclosed a structure-…

: Focal electrical stimulation in the midbrain periaqueductal gray (PAG) or medullary nucleus
raphe magnus (NRM) inhibits spinal nociceptive transmission and nociceptive reflexes. The …

Analogues structurally related to anaplastic lymphoma kinase (ALK) inhibitor 1 were optimized
for metabolic stability. The results from this endeavor not only led to improved metabolic …

… LD Aimone and GF Gebhart … Correspondence should be addressed to LD Aimone at the
above address. … also is unable to block SPA from the PAG (Aimone et al., 1986). Thus, naloxone’…

Members of the JAK family of nonreceptor tyrosine kinases play a critical role in the growth
and progression of many cancers and in inflammatory diseases. JAK2 has emerged as a …

Optimization of a novel series of pyridazin-3-one histamine H 3 receptor (H 3 R) antagonists/inverse
agonists identified 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-…

Anaplastic lymphoma kinase (ALK) is constitutively activated in a number of human cancer
types due to chromosomal translocations, point mutations, and gene amplification and has …

A series of potent vascular endothelial growth factor R2 (VEGF-R2) tyrosine kinase
inhibitors from a new indenopyrrolocarbazole template is reported. The structure−activity …

Several lines of evidence have demonstrated a role for the lateral hypothalamus (LH) in an
endogenous system of descending inhibition. The present study, in rats lightly anesthetized …

Capsaicin has been shown to evoke the release of substance P (SP) from small diameter
primary afferent fibers. Using an in vivo perfusion of the rat spinal cord, this study examined the …