Spike-time precision and network synchrony are controlled by the homeostatic regulation of the D-type potassium current
RH Cudmore, L Fronzaroli-Molinieres… - Journal of …, 2010 - Soc Neuroscience
Homeostatic plasticity of neuronal intrinsic excitability (HPIE) operates to maintain networks
within physiological bounds in response to chronic changes in activity. Classically, this form …
within physiological bounds in response to chronic changes in activity. Classically, this form …
LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels
…, Y Maulet, L Fronzaroli-Molinieres… - Proceedings of the …, 2017 - National Acad Sciences
Autosomal dominant epilepsy with auditory features results from mutations in leucine-rich
glioma-inactivated 1 (LGI1), a soluble glycoprotein secreted by neurons. Animal models of …
glioma-inactivated 1 (LGI1), a soluble glycoprotein secreted by neurons. Animal models of …
[PDF][PDF] Release-dependent variations in synaptic latency: a putative code for short-and long-term synaptic dynamics
…, N Ankri, O Caillard, P Giraud, L Fronzaroli-Molinieres… - Neuron, 2007 - cell.com
In the cortex, synaptic latencies display small variations (∼1–2 ms) that are generally
considered to be negligible. We show here that the synaptic latency at monosynaptically …
considered to be negligible. We show here that the synaptic latency at monosynaptically …
Paired-recordings from synaptically coupled cortical and hippocampal neurons in acute and cultured brain slices
…, RH Cudmore, P Giraud, L Fronzaroli-Molinieres… - Nature protocols, 2008 - nature.com
Abstract Analysis of synaptic transmission, synaptic plasticity, axonal processing, synaptic
timing or electrical coupling requires the simultaneous recording of both the pre- and …
timing or electrical coupling requires the simultaneous recording of both the pre- and …
ATP-P2X7 receptor modulates axon initial segment composition and function in physiological conditions and brain injury
A Del Puerto, L Fronzaroli-Molinieres… - Cerebral …, 2015 - academic.oup.com
Axon properties, including action potential initiation and modulation, depend on both AIS
integrity and the regulation of ion channel expression in the AIS. Alteration of the axon initial …
integrity and the regulation of ion channel expression in the AIS. Alteration of the axon initial …
Presynaptic action potential waveform determines cortical synaptic latency
S Boudkkazi, L Fronzaroli‐Molinieres… - The Journal of …, 2011 - Wiley Online Library
Non‐technical summary Synaptic delay at cortical synapses is determined by the presynaptic
release probability. We show here that the duration and amplitude of the presynaptic …
release probability. We show here that the duration and amplitude of the presynaptic …
[HTML][HTML] Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels
…, M Zbili, A Bialowas, L Fronzaroli-Molinieres… - Nature …, 2015 - nature.com
In the mammalian brain, synaptic transmission usually depends on presynaptic action
potentials (APs) in an all-or-none (or digital) manner. Recent studies suggest, however, that …
potentials (APs) in an all-or-none (or digital) manner. Recent studies suggest, however, that …
The role of hyperpolarization‐activated cationic current in spike‐time precision and intrinsic resonance in cortical neurons in vitro
…, E Carlier, L Fronzaroli‐Molinieres… - The Journal of …, 2011 - Wiley Online Library
Non‐technical summary We determined here the role of the hyperpolarization‐activated
cationic (h) current on the temporal organization of hippocampal activity in vitro. In CA1 …
cationic (h) current on the temporal organization of hippocampal activity in vitro. In CA1 …
Homeostatic regulation of axonal Kv1. 1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit
…, MJ Benitez, L Fronzaroli-Molinieres… - Proceedings of the …, 2021 - National Acad Sciences
Homeostatic plasticity of intrinsic excitability goes hand in hand with homeostatic plasticity
of synaptic transmission. However, the mechanisms linking the two forms of homeostatic …
of synaptic transmission. However, the mechanisms linking the two forms of homeostatic …
GSK3 and β-catenin determines functional expression of sodium channels at the axon initial segment
…, D Sánchez-Ponce, L Fronzaroli-Molinieres… - Cellular and molecular …, 2013 - Springer
Neuronal action potentials are generated through voltage-gated sodium channels, which
are tethered by ankyrinG at the membrane of the axon initial segment (AIS). Despite the …
are tethered by ankyrinG at the membrane of the axon initial segment (AIS). Despite the …