User profiles for Lori L. Isom
Lori IsomMaurice H. Seevers Professor and Chair of Pharmacology, University of Michigan Verified email at umich.edu Cited by 15537 |
Primary Structure and Functional Expression of the β1 Subunit of the Rat Brain Sodium Channel
LL Isom, KS De Jongh, DE Patton, BFX Reber, J Offord… - Science, 1992 - science.org
Voltage-sensitive sodium channels are responsible for the initiation and propagation of the
action potential and therefore are important for neuronal excitability. Complementary DNA …
action potential and therefore are important for neuronal excitability. Complementary DNA …
Auxiliary subunits of voltage-gated ion channels
LL Isom, KS De Jongh, WA Catterall - Neuron, 1994 - Elsevier
The voltage-gated Na+, Ca*+, and K+ channels are responsible for the generation of action
potentials in neurons and other excitable cells. These channels are also involved in cellular …
potentials in neurons and other excitable cells. These channels are also involved in cellular …
Sodium channel β subunits: anything but auxiliary
LL Isom - The Neuroscientist, 2001 - journals.sagepub.com
Voltage-gated sodium channels are glycoprotein complexes responsible for initiation and
propagation of action potentials in excitable cells such as central and peripheral neurons, …
propagation of action potentials in excitable cells such as central and peripheral neurons, …
Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes
Rationale: Plakophilin-2 (PKP2) is an essential component of the cardiac desmosome. Recent
data show that it interacts with other molecules of the intercalated disc. Separate studies …
data show that it interacts with other molecules of the intercalated disc. Separate studies …
[HTML][HTML] Na+ Channel β Subunits: Overachievers of the Ion Channel Family
WJ Brackenbury, LL Isom - Frontiers in pharmacology, 2011 - frontiersin.org
Voltage-gated Na + channels (VGSCs) in mammals contain a pore-forming α subunit and one
or more β subunits. There are five mammalian β subunits in total: β1, β1B, β2, β3, and β4, …
or more β subunits. There are five mammalian β subunits in total: β1, β1B, β2, β3, and β4, …
[HTML][HTML] Differential control of clustering of the sodium channels Nav1. 2 and Nav1. 6 at developing CNS nodes of Ranvier
Na v 1.6 is the main sodium channel isoform at adult nodes of Ranvier. Here, we show that
Na v 1.2 and its β2 subunit, but not Na v 1.6 or β1, are clustered in developing central …
Na v 1.2 and its β2 subunit, but not Na v 1.6 or β1, are clustered in developing central …
Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome
Dravet syndrome (DS) is an intractable developmental and epileptic encephalopathy
caused largely by de novo variants in the SCN1A gene, resulting in haploinsufficiency of the …
caused largely by de novo variants in the SCN1A gene, resulting in haploinsufficiency of the …
[HTML][HTML] Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and-resistant sodium channels in dorsal root ganglion …
S Hong, TJ Morrow, PE Paulson, LL Isom… - Journal of Biological …, 2004 - ASBMB
Diabetic neuropathy is a common form of peripheral neuropathy, yet the mechanisms
responsible for pain in this disease are poorly understood. Alterations in the expression and …
responsible for pain in this disease are poorly understood. Alterations in the expression and …
Mice lacking sodium channel β1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture
…, P Shrager, WA Catterall, LL Isom - Journal of …, 2004 - Soc Neuroscience
Sodium channel β1 subunits modulate α subunit gating and cell surface expression and
participate in cell adhesive interactions in vitro. β1(-/-) mice appear ataxic and display …
participate in cell adhesive interactions in vitro. β1(-/-) mice appear ataxic and display …
[HTML][HTML] Sodium channel β subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact
Sodium channels isolated from mammalian brain are composed of α, β1, and β2 subunits.
The auxiliary β subunits do not form the ion conducting pore, yet play important roles in …
The auxiliary β subunits do not form the ion conducting pore, yet play important roles in …