The synucleins are a unique family of small intracellular proteins that have recently attracted
considerable attention because of their involvement in human neurodegenerative diseases. …

Neurturin (NTN) 1 is a recently identified homologue of glial-cell-line-derived neurotrophic
factor (GDNF) 2 . Both factors promote the survival of a variety of neurons 1 , 2 , 3 , 4 , 5 , and …

The sensory neurons of the embryonic mouse trigeminal ganglion are supported in culture
by different neurotrophins at successive stages of development. Initially the neurons survive …

GFRα-1, GFRα-2, and GFRα-3 constitute a family of structurally related, glycosyl-phosphatidylinosital-linked,
cell surface proteins, two of which, GFRα-1 and GFRα-2, are components of …

Several in vitro and in vivo studies have led to the widely accepted view that NT3 is required
for sympathetic neuroblast survival, induction of TrkA expression and the acquisition of NGF …

Recent work has shown that the survival of the nerve growth factor (NGF)-dependent trigeminal
ganglion neurons of the mouse embryo is promoted by brain-derived neurotrophic factor …

To ascertain the role of endogenous Bcl-2 in maintaining the survival of developing neurons
and modulating their responses to neurotrophins, we compared the in vitro and in vivo …

Synucleins constitute a group of unique, evolutionarily conserved proteins that are expressed
predominantly in neurons of the central and peripheral nervous system. Although the …

Bcl-2 is a cytoplasmic protein that blocks apoptosis in a wide variety of cell types. Here we
report a novel role for Bcl-2 in the early stages of neuronal development. Shortly after …

Natural and induced cell degeneration were studied in the mesencephalic parabigeminal
nucleus of postnatally developing rats. Natural cell death in the normal parabigeminal nucleus …