To determine the physiological roles of peroxisome proliferator-activated receptor β (PPARβ),
null mice were constructed by targeted disruption of the ligand binding domain of the …

Cognitive and motor performance measures are commonly employed in multiple sclerosis (MS)
research, particularly when the purpose is to determine the efficacy of treatment. The …

Impaired manual dexterity is a frequently reported disability in people with multiple sclerosis
(MS) and is increasingly prevalent with worsening disease. While various tests and patient-…

… over time; (c) content and construct validity of the T25FW and its scores; and (d) responsiveness
of the T25FW and clinical meaningfulness of changes in its scores. … Lynn D Hudson …

MicroRNAs (miRNAs) play important roles in modulating gene expression at the
posttranscriptional level. In postnatal oligodendrocyte lineage cells, the miRNA expression profile (“…

To compare effects of insulin-like growth factor I (IGF-I) and placebo treatment on lesions
that resemble those seen during active demyelination in multiple sclerosis, we induced …

Background: The need for more robust outcomes in multiple sclerosis (MS) clinical trials has
been a main priority of the field for decades. Dissatisfaction with existing measures has led …

TPPP/p25, a recently identified tubulin polymerization‐promoting protein (TPPP), is expressed
mainly in myelinating oligodendrocytes of the CNS. Here, we show that TPPP/p25 is …

To investigate insulin-like growth factor I (IGF-I) and IGF-I receptor gene expression during
experimental demyelination and myelin regeneration, young mice were fed cuprizone (( bis(…

The myelin transcription factor 1 (Myt1) gene family is comprised of three zinc finger genes [Myt1,
Myt1L (Myt1‐Like) and NZF3] of the structurally unique CCHHC class that are …