Insulin resistance plays a key role in the development of type 2 diabetes mellitus and is also
associated with several other diseases, such as obesity, hypertension, and cardiovascular …

Background Recent studies showed a link between a high fat diet (HFD)-induced obesity
and lipid accumulation in non-adipose tissues, such as skeletal muscle and liver, and insulin …

The type of free fatty acids (FFAs), saturated or unsaturated, is critical in the development of
insulin resistance (IR), since the degree of saturation correlates with IR. We compared the …

Thiazolidinediones (TZDs), such as troglitazone (TRO) and rosiglitazone (ROSI), improve
insulin resistance by acting as ligands for the nuclear receptor peroxisome proliferator-…

The mitochondrial DNA (mtDNA) of neural stem cells (NSCs) is vulnerable to oxidation
damage. Subtle manipulations of the cellular redox state affect mtDNA integrity in addition to …

… *Address all correspondence and requests for reprints to: Lyudmila I. Rachek, Department
of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama 36688. …

Chronic exposure to elevated levels of free fatty acids (FFAs) impairs pancreatic β-cell
function and contributes to the decline of insulin secretion in type 2 diabetes. Previously, we …

Rickettsia prowazekii, the causative agent of epidemic typhus, is an obligate intracellular
parasitic bacterium that grows directly within the cytoplasm of the eucaryotic host cell. The …

A growing body of evidence indicates that free fatty acids (FFA) can have deleterious effects
on β-cells. It has been suggested that the β-cell dysfunction and death observed in diabetes …

Saturated free fatty acids (FFAs) have been implicated in the increase of oxidative stress,
mitochondrial dysfunction, endoplasmic reticulum (ER) stress, autophagy, and insulin …