Cell lines have provided important experimental tools that have enhanced our understanding
of neural and sensory function. They are particularly valuable in inner ear research …

Deafness is a condition with a high prevalence worldwide, produced primarily by the loss of
the sensory hair cells and their associated spiral ganglion neurons (SGNs). Of all the forms …

The transcription factors GATA3 and Pax2 are expressed throughout development of the
mouse inner ear. We have used antibodies to study their temporal and spatial expression …

Introduction For most types of hearing impairments, a definitive therapy would rest on the
ability to restore hair cells and the spiral ganglion neurons. The only established technique to …

Mammalian cochlear inner hair cells (IHCs) are specialized for the dynamic coding of
continuous and finely graded sound signals. This ability is largely conferred by the linear Ca 2+ …

The function of the zinc finger transcription factor GATA3 was studied in a newly established,
conditionally immortal cell line derived to represent auditory sensory neuroblasts migrating …

… Zine and MN Rivolta: Stem cell based therapy in the inner ear: appropriate donor cell
types and routes for transplantation. Curr Drug Targets, 11(7), 888-97 (2010) … Marcotti …

Mammalian auditory hair cells are few in number, experimentally inaccessible, and do not
proliferate postnatally or in vitro. Immortal cell lines with the potential to differentiate into …

In the quest to develop the tools necessary for a cell-based therapy for deafness, a critical
step is to identify a suitable stem cell population. Moreover, the lack of a self-renovating model …

GATA3 is a transcription factor expressed in the inner ear during the early stages of development.
A monoclonal antibody revealed that it is expressed in spiral ganglion cells and in all …