It has been well established that the volume of secretory vesicles can be modulated. However,
we present the first data demonstrating that the amount of transmitter in a vesicle can …

As a first year, sopho-more or junior student, everyone pays for their S sticker allowing them
to park in Siberia, tne lot past Tinker and behind the soccer field. After two or three years of …

Many spikes in amperometric records of exocytosis events initially exhibit a prespike feature,
or foot, which represents a steady-state flux of neurotransmitter through a stable fusion pore …

… buffer (KG buffer) containing 150 mm potassium glutamate, 20 mm 1,4-piperazine
diethanesulfonic acid, 4 mm EGTA, 1 mmMgCl 2 , 1 mm dithiothreitol, adjusted to pH 7.0 with KOH …

… Prior to imaging, cultures were washed in a physiological saline comprised of 125 m m
NaCl, 5 m m KCl, 1 m m MgCl, 10 m m D-glucose, 2 m m CaCl, 25 m m HEPES. Transfected …

… After being acidified with 2 M HCl, the precipitate was collected by filtration, washed with …
–7b in addition to the [M + ] peak, a fragment ion corresponding to the loss of 4 × COO [M + …

… The adrenal medulla was dissected out in cold Locke's buffer (154 mm NaCl, 5.6 mm KCl,
3.6 mm NaHCO 3 , 5.6 mm glucose, 5.0 mm HEPES, pH 7.4) and then incubated with …

Schizophrenia is one of the most debilitating neuropsychiatric disorders, affecting 0.5–1.0%
of the population worldwide. Its pathology, attributed to defects in synaptic transmission, …

The vesicular monoamine transporter 2 (VMAT2) packages neurotransmitters for release
during neurotransmission and sequesters toxicants into vesicles to prevent neuronal damage. …

… 2 mM in Locke buffer supplemented with 0.7 mM MgCl 2 , without carbonates) towards the
cell surface for 10 s. This configuration allowed to stimulate one cell at a time and to detect its …