There are at least two types of cannabinoid receptors (CB 1 and CB 2 ). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ 9 -…

… Egertova and MR Elphick, unpublished data). Perhaps in these regions of the brain other
fatty-acid-related signalling molecules such as oleamide are regulated by FAAH. Moreover, …

Neuropeptides are a diverse class of neuronal signalling molecules that regulate physiological
processes and behaviour in animals. However, determining the relationships and …

We report the sequence and analysis of the 814-megabase genome of the sea urchin
Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing …

Balanced control of neuronal activity is central in maintaining function and viability of neuronal
circuits. The endocannabinoid system tightly controls neuronal excitability. Here, we show …

The CB 1 ‐type cannabinoid receptor mediates physiologic effects of Δ 9 ‐tetrahydrocannabinol,
the psychoactive ingredient of the drug marijuana. In this report, the authors analyse the …

Fatty acid amide hydrolase (FAAH) catalyses hydrolysis of the endocannabinoid
arachidonoylethanolamide (“anandamide”) in vitro and regulates anandamide levels in the brain. In …

CB1–type cannabinoid receptors in the brain mediate effects of the drug cannabis.
Anandamide and sn–2 arachidonylglycerol (2–AG) are putative endogenous ligands for CB1 …

The sequencing of the Strongylocentrotus purpuratus genome provides a unique opportunity
to investigate the function and evolution of neural genes. The neurobiology of sea urchins …

While evidence implicates the endogenous cannabinoid system as a novel analgesic target
at a spinal level, detailed analysis of the distribution of the cannabinoid receptor CB 1 in …