Cellular mechanisms of neurogenic inflammation
JD Richardson, MR Vasko - Journal of Pharmacology and Experimental …, 2002 - ASPET
Since the initial observations that stimulation of sensory neurons produces vasodilation, plasma
extravasation, and hypersensitivity, much progress has been made in understanding the …
extravasation, and hypersensitivity, much progress has been made in understanding the …
Peripheral mechanisms of pain and analgesia
This review summarizes recent findings on peripheral mechanisms underlying the generation
and inhibition of pain. The focus is on events occurring in peripheral injured tissues that …
and inhibition of pain. The focus is on events occurring in peripheral injured tissues that …
DNA repair in neurons: so if they don't divide what's to repair?
ML Fishel, MR Vasko, MR Kelley - Mutation Research/Fundamental and …, 2007 - Elsevier
Neuronal DNA repair remains one of the most exciting areas for investigation, particularly
as a means to compare the DNA repair response in mitotic (cancer) vs. post-mitotic (neuronal) …
as a means to compare the DNA repair response in mitotic (cancer) vs. post-mitotic (neuronal) …
Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C
JC Fehrenbacher, CP Taylor, MR Vasko - Pain, 2003 - journals.lww.com
Gabapentin and pregabalin are amino acid derivatives of γ-amino butyric acid that have
anticonvulsant, analgesic, and anxiolytic-like properties in animal models. The mechanisms of …
anticonvulsant, analgesic, and anxiolytic-like properties in animal models. The mechanisms of …
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex
The use of N-type voltage-gated calcium channel (CaV2.2) blockers to treat pain is limited
by many physiological side effects. Here we report that inflammatory and neuropathic …
by many physiological side effects. Here we report that inflammatory and neuropathic …
Furosemide absorption altered in decompensated congestive heart failure
MR Vasko, D BROWN-CARTWRIGHT… - Annals of internal …, 1985 - acpjournals.org
We assessed whether patients with decompensated congestive heart failure had altered
absorption of oral furosemide. Pharmacokinetic and pharmacodynamic responses were studied …
absorption of oral furosemide. Pharmacokinetic and pharmacodynamic responses were studied …
Models of inflammation: carrageenan‐or complete freund's adjuvant (CFA)–induced edema and hypersensitivity in the rat
JC Fehrenbacher, MR Vasko… - Current protocols in …, 2012 - Wiley Online Library
Animal models of inflammation are used to assess the production of inflammatory mediators
at sites of inflammation, the anti‐inflammatory properties of agents such as nonsteroidal anti…
at sites of inflammation, the anti‐inflammatory properties of agents such as nonsteroidal anti…
[HTML][HTML] Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?
GD Nicol, MR Vasko - Molecular interventions, 2007 - triggered.clockss.org
Nerve Growth Factor (NGF) is produced by and affects a number of immune and inflammatory
cells. As part of the inflammatory response, NGF directly or indirectly alters the sensitivity …
cells. As part of the inflammatory response, NGF directly or indirectly alters the sensitivity …
[HTML][HTML] Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons
MD Southall, MR Vasko - Journal of Biological Chemistry, 2001 - ASBMB
Although a number of prostaglandin E 2 (PGE 2 ) receptor subtypes have been cloned, limited
studies have been performed to elucidate subtypes that subserve specific actions of this …
studies have been performed to elucidate subtypes that subserve specific actions of this …
Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture
MR Vasko, WB Campbell, KJ Waite - Journal of Neuroscience, 1994 - Soc Neuroscience
Prostaglandins are known to enhance the inflammatory and nociceptive actions of other
chemical mediators of inflammation such as bradykinin. One possible mechanism for this …
chemical mediators of inflammation such as bradykinin. One possible mechanism for this …