Cellular mechanisms of neurogenic inflammation

JD Richardson, MR Vasko - Journal of Pharmacology and Experimental …, 2002 - ASPET
Since the initial observations that stimulation of sensory neurons produces vasodilation, plasma
extravasation, and hypersensitivity, much progress has been made in understanding the …

Peripheral mechanisms of pain and analgesia

C Stein, JD Clark, U Oh, MR Vasko, GL Wilcox… - Brain research …, 2009 - Elsevier
This review summarizes recent findings on peripheral mechanisms underlying the generation
and inhibition of pain. The focus is on events occurring in peripheral injured tissues that …

DNA repair in neurons: so if they don't divide what's to repair?

ML Fishel, MR Vasko, MR Kelley - Mutation Research/Fundamental and …, 2007 - Elsevier
Neuronal DNA repair remains one of the most exciting areas for investigation, particularly
as a means to compare the DNA repair response in mitotic (cancer) vs. post-mitotic (neuronal) …

Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C

JC Fehrenbacher, CP Taylor, MR Vasko - Pain, 2003 - journals.lww.com
Gabapentin and pregabalin are amino acid derivatives of γ-amino butyric acid that have
anticonvulsant, analgesic, and anxiolytic-like properties in animal models. The mechanisms of …

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

…, X Jin, A Shekhar, XM Xu, GS Oxford, MR Vasko… - Nature medicine, 2011 - nature.com
The use of N-type voltage-gated calcium channel (CaV2.2) blockers to treat pain is limited
by many physiological side effects. Here we report that inflammatory and neuropathic …

Furosemide absorption altered in decompensated congestive heart failure

MR Vasko, D BROWN-CARTWRIGHT… - Annals of internal …, 1985 - acpjournals.org
We assessed whether patients with decompensated congestive heart failure had altered
absorption of oral furosemide. Pharmacokinetic and pharmacodynamic responses were studied …

Models of inflammation: carrageenan‐or complete freund's adjuvant (CFA)–induced edema and hypersensitivity in the rat

JC Fehrenbacher, MR Vasko… - Current protocols in …, 2012 - Wiley Online Library
Animal models of inflammation are used to assess the production of inflammatory mediators
at sites of inflammation, the anti‐inflammatory properties of agents such as nonsteroidal anti…

[HTML][HTML] Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?

GD Nicol, MR Vasko - Molecular interventions, 2007 - triggered.clockss.org
Nerve Growth Factor (NGF) is produced by and affects a number of immune and inflammatory
cells. As part of the inflammatory response, NGF directly or indirectly alters the sensitivity …

[HTML][HTML] Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons

MD Southall, MR Vasko - Journal of Biological Chemistry, 2001 - ASBMB
Although a number of prostaglandin E 2 (PGE 2 ) receptor subtypes have been cloned, limited
studies have been performed to elucidate subtypes that subserve specific actions of this …

Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture

MR Vasko, WB Campbell, KJ Waite - Journal of Neuroscience, 1994 - Soc Neuroscience
Prostaglandins are known to enhance the inflammatory and nociceptive actions of other
chemical mediators of inflammation such as bradykinin. One possible mechanism for this …